Determination of 17-hydroxycorticosteroids in dialysate solution as a measure of adrenocortical function in hemodialysis patients
| Autor: | Ryoji Hiramatsu, Tatsuo Sato, Kuniharu Kuwahara, Yukimasa Kohda |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Hydrocortisone medicine.medical_treatment Urology Dexamethasone Renal Dialysis Internal medicine Dialysis Solutions medicine Humans Aged 17-Hydroxycorticosteroids Adrenal cortex business.industry Hydroxycorticosteroids Middle Aged medicine.anatomical_structure Endocrinology Evaluation Studies as Topic Adrenal Cortex Female sense organs Hemodialysis Adrenal Cortex Function Tests business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Nephron. 66(1) |
| ISSN: | 1660-8151 |
| Popis: | Dialysate contents of 17-hydroxycorticosteroids (17-OHCS) in hemodialysis patients were studied as a potential measure of adrenocortical function. Dialysate 17-OHCS contents after a 2-day interval of hemodialysis in 15 hemodialysis patients were determined. Dialysate 17-OHCS increased after intravenous injection of cortisol the evening prior to hemodialysis (n = 4). Dialysate 17-OHCS content was suppressed, as was plasma cortisol, after a standard dexamethasone (Dex) suppression test (n = 1). Their plasma cortisol was suppressible or nonsuppressible by an overnight Dex suppression test, as reported previously. However, basal dialysate 17-OHCS contents were not different between them, indicating that the nonsuppressible patients with overnight Dex seem not to have hypercortisolism. We conclude that determination of dialysate 17-OHCS seems a useful noninvasive technique for the evaluation of adrenocortical function in hemodialysis patients. |
| Databáze: | OpenAIRE |
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