Emerging concepts in the regulation of the EGF receptor and other receptor tyrosine kinases
| Autor: | John Kuriyan, Aaron J. Cantor, Tiago Barros, Nicholas F. Endres |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
G protein-coupled receptor kinase
EGF Family of Proteins biology Protein Conformation Cell Membrane GRB7 JAK-STAT signaling pathway Receptor Protein-Tyrosine Kinases Ligands Biochemistry Receptor tyrosine kinase Cell biology Protein Structure Tertiary Enzyme Activation ErbB Receptors ROR1 biology.protein Humans NCK1 Signal transduction Protein Multimerization Molecular Biology Proto-oncogene tyrosine-protein kinase Src |
| Zdroj: | Trends in biochemical sciences. 39(10) |
| ISSN: | 0968-0004 |
| Popis: | The activation of receptor tyrosine kinases in response to extracellular signals is a principal component of metazoan signaling. Structural analysis of the extracellular and intracellular domains of these receptors has shed substantial light on the mechanisms underlying their activation. A remaining challenge is to understand how these domains operate together in the context of the full-length receptors. With a focus on the epidermal growth factor (EGF) receptor, this review highlights recent advances towards this goal. Although receptor tyrosine kinases are divergent in terms of the details of how they operate, these studies reveal common mechanisms that ensure activation in the proper context. Understanding these mechanisms provides insights into the vulnerabilities of these receptors to disease-causing mutations. |
| Databáze: | OpenAIRE |
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