Biomedical applications of yeasts - a patent view, part two: era of humanized yeasts and expanded applications
| Autor: | Parastoo Ehsani, Farzin Roohvand, Meghdad Abdollahpour-Alitappeh, Mehdi Shokri, Niloufar Kossari |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Glycosylation
Gastrointestinal Diseases Computational biology 01 natural sciences Antibodies Yeast gene Genome engineering Patents as Topic 03 medical and health sciences chemistry.chemical_compound Drug Delivery Systems 0302 clinical medicine Neoplasms Yeasts Drug Discovery Animals Humans Glycoproteins Pharmacology biology Probiotics Point mutation Substitution (logic) General Medicine biology.organism_classification Yeast High-Throughput Screening Assays 0104 chemical sciences Saccharomyces boulardii 010404 medicinal & biomolecular chemistry chemistry 030220 oncology & carcinogenesis Functional genomics |
| Zdroj: | Expert Opinion on Therapeutic Patents. 30:609-631 |
| ISSN: | 1744-7674 1354-3776 |
| DOI: | 10.1080/13543776.2020.1781816 |
| Popis: | Yeast humanization, ranging from a simple point mutation to substitution of yeast gene(s) or even a complete pathway by human counterparts has enormously expanded yeast biomedical applications.General and patent-oriented insights into the application of native and humanized yeasts for production of human glycoproteins (gps) and antibodies (Abs), toxicity/mutagenicity assays, treatments of gastrointestinal (GI) disorders and potential drug delivery as a probiotic (with emphasis onHumanized yeasts cover the classical advantageous features of a 'microbial eukaryote' together with advanced human cellular processes. These unique characteristics would permit their use in the production of functional and stable therapeutic gps and Abs in lower prices compared to mammalian (CHO) production-based systems. Availability of yeasts humanized for cytochrome P450 s will expand their application in metabolism-related chemical toxicity assays. Engineered |
| Databáze: | OpenAIRE |
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