The association between serum alanine aminotransferase and hypertension: A national based cross-sectional analysis among over 21 million Chinese adults
| Autor: | Ying Yang, Xu Ma, Puhong Zhang, Fangchao Liu, Zuoqi Peng, Qin Xu, Jiajing Jia, Ya Zhang, Haiping Shen, Yiping Zhang, Tonglei Guo, Long Wang, Yuan He, Minjin Zhang, Donghai Yan, Yuanyuan Wang, Hongguang Zhang |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male lcsh:Diseases of the circulatory (Cardiovascular) system medicine.medical_specialty China Cross-sectional study Population Diastole 030209 endocrinology & metabolism Blood Pressure 030204 cardiovascular system & hematology Overweight Logistic regression Gastroenterology Risk Assessment 03 medical and health sciences Young Adult 0302 clinical medicine Liver Function Tests Risk Factors Internal medicine medicine Prevalence Humans education education.field_of_study business.industry Liver Diseases Confounding Alanine Transaminase Odds ratio Clinical Enzyme Tests Middle Aged Prognosis Blood pressure Cross-Sectional Studies lcsh:RC666-701 Hypertension Alanine aminotransferase Female medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers Research Article |
| Zdroj: | BMC Cardiovascular Disorders BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-12 (2021) |
| ISSN: | 1471-2261 |
| Popis: | Background Inconsistent results were found in the association between serum alanine aminotransferase (ALT) and hypertension among population-based studies. This study evaluated the association between ALT and hypertension among Chinese reproductive-age population by utilizing registration data from National Free Pre-pregnancy Checkups Project in 2016–2017. Methods The 21,103,790 registered participants were eligible for analysis, including women who were 20–49 years old and men who were 20–59 years old with available data for ALT and blood pressure (BP). Logistic regression was conducted to estimate odds ratio (OR) for the association between ALT and hypertension as a binary outcome. Linear regression was used to examine the association between ALT and BP as a continuous outcome. Results In total, 4.21% of the participants were hypertensive, and 11.67% had elevated ALT (> 40 U/L). Hypertension prevalence was 3.63% and 8.56% among participants with normal and elevated ALT levels. A strong linear relationship was found between serum ALT levels and the odds of hypertension after adjustment for potential confounders. The multivariable-adjusted ORs for hypertension were 1, 1.22 (1.21, 1.22), 1.67 (1.65 1.68), 1.78 (1.76, 1.80), and 1.92 (1.90, 1.94) in participants with ALT levels of ≤ 20, 20.01–40, 40.01–60, 60.01–80, and > 80 U/L, respectively. Systolic and diastolic BPs rose by 1.83 and 1.20 mmHg on average, for each 20 U/L increase in ALT (P for trend 2) (χ2 = 52,228, P 2 = 100,730, P 2 = 105,347, P Conclusions Our cross-sectional analysis suggested a linear association between serum ALT and hypertension or BP, which indicated that abnormal liver metabolism marked by elevated serum ALT could play a role in hypertension or elevated BP condition. |
| Databáze: | OpenAIRE |
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