Cartilage lamina splendens inspired nanostructured coating for biomaterial lubrication
| Autor: | Hongping Wan, Prashant K. Sharma, Hans J. Kaper, Ke Ren |
|---|---|
| Přispěvatelé: | Personalized Healthcare Technology (PHT), Man, Biomaterials and Microbes (MBM) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cartilage
Articular Materials science Friction Boundary lubrication INTERSTITIAL FLUID PRESSURIZATION FRICTION TRAUMA Biocompatible Materials 02 engineering and technology Surface finish engineering.material 010402 general chemistry 01 natural sciences Biomaterials Coating chemistry.chemical_compound Colloid and Surface Chemistry SYNOVIAL-FLUID X-ray photoelectron spectroscopy Lubrication TFOS INTERNATIONAL WORKSHOP Hyaluronic Acid SYNERGY Carbodiimide chemistry.chemical_classification LUBRICIN Biomaterial Implant HYALURONIC-ACID POLYMER Polymer 021001 nanoscience & nanotechnology 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Cartilage Chemical engineering chemistry MENISCUS engineering Wetting 0210 nano-technology |
| Zdroj: | Journal of Colloid and Interface Science, 594, 435-445. ACADEMIC PRESS INC ELSEVIER SCIENCE |
| ISSN: | 0021-9797 |
| Popis: | Biomaterials that are used in biological systems, such as polycarbonate urethane (PCU) knee joint implants and contact lenses, generally lack lubrication. This limits their integration with the body and impedes their function. Here, we propose a nanostructured film based on hydrophilic polysaccharide hyaluronic acid conjugated with dopamine (HADN) and zwitterionic reduced glutathione (Glu), which forms a composite coating (HADN-Glu) to enhance the lubrication between cartilage and PCU. HADN was synthesized by carbodiimide chemistry between hyaluronic acid and dopamine and deposited on PCU surface under mild oxidative conditions. Then, zwitterionic peptide-reduced glutathione was bioconjugated to HADN, forming a lubrication film. Analysis based on X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM) and wettability indicated that HADN and Glu had grafted successfully onto the PCU surface. Measurements of the coefficient of friction (COF), friction energy dissipation and cartilage roughness indicated that cartilage was effectively protected by the high lubrication of HADN-Glu. Both at low and high applied loads, this effect was likely due to the enhanced boundary lubrication enabled by HADN-Glu on the PCU surface. Moreover, HADN-Glu is highly biocompatible with chondrocyte cells, suggesting that this film will benefit the design of implants where lubrication is needed. |
| Databáze: | OpenAIRE |
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