Deep venous thrombosis caused by congenital absence of inferior vena cava, combined with hyperhomocysteinemia
| Autor: | Do Sang Lee, Gi Young Sung, Kee Hwan Kim, In Sung Moon, Young Bok Koh, Sang Seob Yun, Jeong Soo Kim, Ji Il Kim, Keun Woo Lim |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Hyperhomocysteinemia medicine.medical_specialty Chronic venous insufficiency Deep vein Cardiovascular Abnormalities Vena Cava Inferior Inferior vena cava Venous stasis medicine Humans cardiovascular diseases Methylenetetrahydrofolate Reductase (NADPH2) Venous Thrombosis biology business.industry Anticoagulants General Medicine medicine.disease Thrombosis Surgery Venous thrombosis medicine.anatomical_structure medicine.vein Methylenetetrahydrofolate reductase Mutation cardiovascular system biology.protein Female Cardiology and Cardiovascular Medicine business Magnetic Resonance Angiography |
| Zdroj: | Annals of vascular surgery. 18(1) |
| ISSN: | 0890-5096 |
| Popis: | We present a case of suprarenal and infrarenal absence of the inferior vena cava, combined with hyperhomocysteinemia in a 39-year-old woman who presented with symptoms of deep venous thrombosis. The patient also had a homozygous mutation of C677T methylenetetrahydrofolate reductase. Deep vein thrombosis has a multifactorial etiology involving both genetic and acquired factors. Absence of the inferior vena cava is a rare congenital anomaly, but recently it was confirmed as an important risk factor for the development of deep vein thrombosis, especially in young persons. Hypercoagulability due to hyperhomocysteinemia with a tendency toward venous stasis, mediated by congenital absence of the inferior vena cava is thought to have caused deep vein thrombosis in our patient. To our knowledge, this association has not yet been reported. The clinical features and prognosis of this entity are discussed. |
| Databáze: | OpenAIRE |
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