The relationship between serum lithium levels and clinical response
| Autor: | Sashidharan Sp |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Pharmacology
medicine.medical_specialty Bipolar Disorder Lithium (medication) business.industry Lithium Mental illness medicine.disease Indirect evidence Kinetics Pharmacokinetics Serum lithium level Treatment study Internal medicine medicine Humans Pharmacology (medical) Limited evidence medicine.symptom business Mania medicine.drug |
| Zdroj: | Therapeutic drug monitoring. 4(3) |
| ISSN: | 0163-4356 |
| Popis: | A guiding principle in the use of lithium salts in the treatment of mental illness is to maintain the serum lithium level between 0.8 and 1.2 mmol/L. This article reviews the limited evidence on which such a recommendation is male. The pharmacokinetics of lithium ion and difficulties inherent in serum lithium estimation are briefly examined. Clinical studies which looked specifically for a relationship between lithium dosage and serum concentration are reviewed. Treatment studies of lithium in mania and prophylaxis of affective disorders are assessed for indirect evidence to support a relationship between favorable therapeutic outcome and recommended serum levels. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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