Connector sensors for permittivity-based thrombus monitoring in extracorporeal life support
| Autor: | Masahiro Takei, Hideaki Haneishi, Hanako Tatekawa, Madoka Koishi, Martin Wekesa Sifuna, Achyut Sapkota, Takuo Uemura |
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| Rok vydání: | 2019 |
| Předmět: |
Permittivity
Extracorporeal Circulation Materials science Interface (computing) 0206 medical engineering Biomedical Engineering Medicine (miscellaneous) 02 engineering and technology 030204 cardiovascular system & hematology Extracorporeal Biomaterials 03 medical and health sciences Cable gland 0302 clinical medicine Extracorporeal Membrane Oxygenation Optical coherence tomography medicine Animals Tube (fluid conveyance) Thrombus medicine.diagnostic_test Extracorporeal circulation Thrombosis medicine.disease 020601 biomedical engineering sense organs Cardiology and Cardiovascular Medicine Tomography Optical Coherence Biomedical engineering |
| Zdroj: | Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs. 24(1) |
| ISSN: | 1619-0904 |
| Popis: | Extracorporeal circulation is vital in cardiovascular surgery, but thrombus formation at connector interface is a major threat. Optical coherence tomography (OCT) is presently used to monitor thrombogenesis at connectors, but it is expensive to install and complex to use. This study fabricated and evaluated a connector sensor for real-time permittivity-based thrombus monitoring at tube–connector interface. Computational simulations were initially done to pre-evaluate the applicability of connector sensor. The sensor was fabricated by incorporating two stainless steel electrodes on acrylic tube for measuring permittivity changes at the tube–connector interface. OCT images were also taken from the interface at intervals for comparisons. Results show that the sensor was able to detect thrombus formation at the interface in form of sudden rise in permittivity after time t = 9 min. The permittivity changes were confirmed by OCT images which showed thrombus formation after time t = 14 min implying that permittivity changes were due to regional aggregation of red blood cells. The connector sensor is therefore envisioned as an affordable alternative to OCT for real-time permittivity-based monitoring of thrombogenesis at tube–connector interface. |
| Databáze: | OpenAIRE |
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