A novel delivery system for supraglottic atomization allows increased lung deposition rates of pulmonary surfactant in newborn piglets
| Autor: | Ilaria Milesi, Raffaele Dellaca, Marco Di Castri, Emanuela Zannin, Federico Bianco, Anders Nord, Doris Cunha-Goncalves, Valeria Perez-de-Sa, Rikard Linner |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Catheters Drug Compounding medicine.medical_treatment Sus scrofa 03 medical and health sciences Drug Delivery Systems 0302 clinical medicine Pulmonary surfactant 030225 pediatrics Administration Inhalation medicine Animals Poractant alfa Tissue Distribution Continuous positive airway pressure Lung Phospholipids Aerosolization Aerosols Biological Products Inhalation business.industry Nebulizers and Vaporizers Technetium Pulmonary Surfactants Equipment Design Basic Science Article Cannula medicine.anatomical_structure Animals Newborn Anesthesia Pediatrics Perinatology and Child Health Breathing Feasibility Studies Female business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Pediatric Research |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1038/s41390-019-0696-x |
| Popis: | Background Earlier attempts to deliver effective lung doses of surfactant by aerosolization were unsuccessful, mostly because of technical shortcomings. We aimed at quantifying the lung deposition of poractant alfa with a new supraglottic delivery system for surfactant atomization in an experimental neonatal model. Methods The method involved six sedated 1-day-old piglets lying in the lateral decubitus, spontaneously breathing on nasal-mask continuous positive airway pressure (nCPAP). A pharyngeal cannula housing a multi-channel air-blasting atomization catheter was placed through the mouth with its tip above the glottis entrance. In all, 200 mg kg−1 of a 99mTc-surfactant mixture was atomized through the catheter synchronously with inspiration. Six intubated control piglets received an equal amount of intratracheally instilled 99mTc-surfactant mixture. The percentage of the 99mTc-surfactant mixture deposited in the lungs was estimated by scintigraphy. Results Median (range) deposition in the lungs was 40% (24–68%) after atomization and 87% (55–95%) after instillation (p |
| Databáze: | OpenAIRE |
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