An fMRI-compatible force measurement system for the evaluation of the neural correlates of step initiation
| Autor: | Daniel Boari Coelho, Luis Augusto Teixeira, Egberto Reis Barbosa, Catarina Costa Boffino, Ellison Fernando Cardoso, Sukhwinder S. Shergill, Rachael Brant, Raymundo Machado de Azevedo Neto, Edson Amaro, Rajal G. Cohen, Andrea Cristina de Lima-Pardini, Carolina de Oliveira Souza, Fay B. Horak |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty 050105 experimental psychology Article 03 medical and health sciences 0302 clinical medicine Physical medicine and rehabilitation Gait (human) Neuroimaging Postural Balance medicine Humans 0501 psychology and cognitive sciences DOENÇA DE PARKINSON Gait Aged Mechanical Phenomena Neural correlates of consciousness Multidisciplinary Supplementary motor area medicine.diagnostic_test business.industry System of measurement 05 social sciences Motor Cortex Magnetic resonance imaging Parkinson Disease Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure Female business Functional magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Scientific Reports |
| Popis: | Knowledge of brain correlates of postural control is limited by the technical difficulties in performing controlled experiments with currently available neuroimaging methods. Here we present a system that allows the measurement of anticipatory postural adjustment of human legs to be synchronized with the acquisition of functional magnetic resonance imaging data. The device is composed of Magnetic Resonance Imaging (MRI) compatible force sensors able to measure the level of force applied by both feet. We tested the device in a group of healthy young subjects and a group of elderly subjects with Parkinson’s disease using an event-related functional MRI (fMRI) experiment design. In both groups the postural behavior inside the magnetic resonance was correlated to the behavior during gait initiation outside the scanner. The system did not produce noticeable imaging artifacts in the data. Healthy young people showed brain activation patterns coherent with movement planning. Parkinson’s disease patients demonstrated an altered pattern of activation within the motor circuitry. We concluded that this force measurement system is able to index both normal and abnormal preparation for gait initiation within an fMRI experiment. |
| Databáze: | OpenAIRE |
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