Supplementary Data from High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer

Autor: Jacek Otlewski, Malgorzata Zakrzewska, Aleksandra Borek, Julia Chudzian, Grzegorz Chodaczek, Aleksandra Sokolowska-Wedzina
Rok vydání: 2023
DOI: 10.1158/1541-7786.22511946.v1
Popis: Supplementary Materials and Methods - Description of affinity maturation procedure used in the study and of the preparation of scFvD2 diabody and scFvD2-Fc; Supplementary Figure S1 - Reactivity of scFv clones against Fc fragment; Supplementary Figure S2 - Characteristics of affinity maturated scFvE2 clone; Supplementary Figure S3 - Lack of activation of FGFR1 by D2 antibodies; Supplementary Figure S4 - Internalization of FGF2 by lung cancer cells; Supplementary Figure S5 - Level of FGFR1 and internalization process of scFvD2-Fc by NCI-H1581 cells.
Databáze: OpenAIRE