Absence of a positive outcome bias in randomized controlled trials of minimally invasive surgical techniques
| Autor: | Soum D. Lokeshwar, Christopher J.D. Wallis, Zachary Klaassen, Caitlin E. Jones, David Tella, Rashid K. Sayyid |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Surgical approach Impact factor Epidemiology business.industry MEDLINE Regression analysis Outcome (game theory) Confidence interval law.invention 03 medical and health sciences 0302 clinical medicine Primary outcome Randomized controlled trial law Internal medicine Humans Minimally Invasive Surgical Procedures Medicine 030212 general & internal medicine business Publication Bias 030217 neurology & neurosurgery Randomized Controlled Trials as Topic |
| Zdroj: | Journal of Clinical Epidemiology. 131:163-165 |
| ISSN: | 0895-4356 |
| Popis: | Objective To determine whether a positive primary outcome in randomized controlled trials of minimally invasive surgical techniques predicted publication in higher impact factor journals. Study Design and Setting A systematic review of EMBASE (OvidSP®), MEDLINE (OvidSP®), and Cochrane (Wiley®) databases from inception to December 22, 2017 was performed to identify all randomized controlled trials comparing minimally invasive and classical surgical techniques. Our primary study outcome was journal “corrected impact factor”, accounting for journal impact factor inflation over more recent publication years. Sensitivity analyses with impact factor operationalized in five additional ways was performed. Univariable and multivariable gamma regression analyses were used to evaluate the association of a positive primary outcome and journal “corrected impact factor”. Results 410 studies were identified. On multivariable gamma regression analysis, a positive primary outcome was not associated with a higher likelihood of publication in a higher impact factor journal (coefficient 1.05, 95% Confidence Interval 0.82-1.35, p= 0.66), with similar negative results consistently demonstrated in all sensitivity analyses performed. Conclusion In a systematic review of randomized controlled trials of minimally invasive surgical approaches over the last 20 years, we failed to find evidence that the minimally invasive surgical literature is subject to a positive outcome bias. |
| Databáze: | OpenAIRE |
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