A 41-kDa antigen of the rodent filaria Acanthocheilonema viteae with homologies to tropomyosin induces host-protective immune responses
| Autor: | Susanne Hartmann, Ralf Adam, Richard Lucius, Silvia Seidinger, Christa Kirsten, Thomas M. Marti |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Rodent Molecular Sequence Data Helminthiasis Tropomyosin Dipetalonema Microbiology Rodent Diseases Immune system Antigen Dipetalonema Infections biology.animal parasitic diseases medicine Animals Parasite hosting Amino Acid Sequence Peptide sequence Acanthocheilonema viteae Sequence Homology Amino Acid General Veterinary biology Vaccination General Medicine biology.organism_classification medicine.disease Virology Infectious Diseases Antigens Helminth Insect Science Female Parasitology Gerbillinae Sequence Analysis |
| Zdroj: | Parasitology Research. 83:390-393 |
| ISSN: | 1432-1955 0932-0113 |
| DOI: | 10.1007/s004360050269 |
| Popis: | A purified 41-kDa protein of the rodent filaria Acanthocheilonema viteae was shown to protect jirds against a challenge infection. Subcutaneous immunization with the protein reduced the number of adult worms by up to 65% and the number of circulating microfilariae declined by up to 93% in these animals. The protein is located in the muscle tissues of adult worms and was identified as tropomyosin by N-terminal sequencing of the purified protein. |
| Databáze: | OpenAIRE |
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