High dose of standardised extract ofCostus aferleaves potentiates cadmium reproductive toxicity in Wistar rats
| Autor: | Tope Gafar Atere, Oluseyi Adeboye Akinloye |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Cadmium Poisoning Antioxidant Urology medicine.medical_treatment 030232 urology & nephrology chemistry.chemical_element Pharmacology Cadmium chloride Testicular Diseases Antioxidants Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Cadmium Chloride Testis medicine Animals Humans Rats Wistar chemistry.chemical_classification Cadmium 030219 obstetrics & reproductive medicine Dose-Response Relationship Drug Plant Extracts business.industry Glutathione peroxidase Costus General Medicine Glutathione Sperm Rats Plant Leaves Disease Models Animal Oxidative Stress chemistry Lipid Peroxidation Reproductive toxicity business |
| Zdroj: | Andrologia. 51 |
| ISSN: | 1439-0272 0303-4569 |
| Popis: | Protective effects of standardised extract of Costus afer leaves (CAME), an extract with good antioxidants on cadmium-induced reproductive toxicity in male rats, were investigated in this study. Forty-two adult male Wistar rats were randomly divided into six groups and were treated every day regularly for 4 weeks. G1 (control) rats received 1 ml of vehicle treatment. G2 rats were intoxicated with 2.5 mg kg-1 day-1 s.c cadmium chloride for 1 week. G3 and G4 rats were intoxicated with cadmium as in G2 rats and were treated orally with 100 and 200 mg/kg bwt/day of CAME, respectively, for 4 weeks. Group G5 and G6 rats were orally treated with 100 and 200 mg kg-1 day-1 bwt of CAME, respectively, for 4 weeks. Significant changes (p |
| Databáze: | OpenAIRE |
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