Determination of the relative avidity of the specific IgG antibodies in human toxocariasis
| Autor: | B. Machnicka, H. Żarnowska, E. Dziemian, M. Kołodziej-Sobocińska |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Time Factors Adolescent Immunology Antibodies Helminth Antibody Affinity chemical and pharmacologic phenomena medicine Animals Humans Avidity Child Low avidity Toxocara Toxocariasis biology Zoonosis Specific igg Igg avidity medicine.disease biology.organism_classification Virology Child Preschool Immunoglobulin G biology.protein Parasitology Female Antibody Toxocara canis |
| Zdroj: | Parasite immunology. 30(3) |
| ISSN: | 1365-3024 |
| Popis: | SUMMARY Human toxocariasis is a zoonosis caused by infection with larvae of the ascarid nematode Toxocara canis and, less frequently, T. cati. Our study developed a method for distinguishing distant from recent human toxocariasis by assessing the avidity of the IgG antibodies. The avidity of specific antibodies increases with time after antigen challenge and assessment of the degree of avidity can be used to discriminate between recent and distant infections. The relative avidity was measured in 150 sera from children with visceral toxocariasis and in 46 sera from children with ocular toxocariasis. The probable time of infection was estimated on the basis of the medical history and clinical syndrome. Our study showed that 94·2% of positive sera collected from patients reporting infection > 6 months ago had high IgG avidity values, confirming distant toxocariasis, whereas 25·9% of positive sera taken |
| Databáze: | OpenAIRE |
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