Proprotein convertase 1/3 inhibited macrophages: A novel therapeutic based on drone macrophages

Autor: Michel Salzet, Adriana Murgoci, Robert Day, Isabelle Fournier, Franck Rodet, Marie Duhamel, Maxence Wisztorski
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
endocrine system
lcsh:QH426-470
TLR
toll like receptor
education
Special Section: Proceedings of the 9th Annual EuPA Congress “Proteomics - Back to the Future” (June 23 - 28
2015
Milano
Italy)
Proprotein convertase 1
Context (language use)
Biology
Biochemistry
03 medical and health sciences
CXCL
chemokine (C–X–C motif) ligand
medicine
Secretion
CCL
chemokine (C–C motif) ligand
ComputingMethodologies_COMPUTERGRAPHICS
KD
knockdown
Gene knockdown
NT
non-target
fungi
TAM
tumor associated macrophages
PC
proprotein convertase
medicine.disease
Proprotein convertase
MVB
multivesicular bodies
Cell biology
lcsh:Genetics
030104 developmental biology
Immunology
TLR4
behavior and behavior mechanisms
LPS
lipopolysaccharides
Signal transduction
Cytokine storm
psychological phenomena and processes
Zdroj: EuPA Open Proteomics, Vol 11, Iss C, Pp 20-22 (2016)
EuPA Open Proteomics
ISSN: 2212-9685
Popis: Graphical abstract Schematic depicting how PC1/3 knockdown impacts macrophage activation based on the data presented.
Highlights • Proprotein convertase 1/3 knockdown or knockout macrophages present all the characteristic of activated pro-inflammatory macrophages. • Under LPS, PC1/3 inhibition in macrophages leads to secretion of inflammatory and antitumor factors. • Proprotein convertase 1/3 inhibited macrophages can act as “drone macrophages” by reactivation at distance. • Proprotein convertase 1/3 inhibited macrophages constitute an innovative cell therapy to treat efficiently tumors.
We demonstrated here thanks to proteomic, that proprotein convertase 1/3 knockdown macrophages present all the characteristic of activated pro-inflammatory macrophages. TLR4 and TLR9 signaling pathways can be enhanced leading to the secretion of pro-inflammatory factors and antitumor factors. We can control their activation by controlling one enzyme, PC1/3. In a tumor context, PC1/3 inhibition in macrophages may reactivate them and lead to a cytokine storm after stimulation “at distance” with a TLR ligand. Therefore, we name these proprotein convertase inhibited macrophages the “drone macrophages”. They constitute an innovative cell therapy to treat efficiently tumors.
Databáze: OpenAIRE
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