A Special Population of Regulatory T Cells Potentiates Muscle Repair
| Autor: | Dalia Burzyn, Esen Sefik, Tze Guan Tan, Amy J. Wagers, Massimiliano Cerletti, Christophe Benoist, Jennifer L. Shadrach, Diane Mathis, Wilson Kuswanto, Dmitriy Kolodin, Young C. Jang |
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| Rok vydání: | 2013 |
| Předmět: |
EGF Family of Proteins
Lymphoid Tissue T cell Population Receptors Antigen T-Cell chemical and pharmacologic phenomena Biology Amphiregulin T-Lymphocytes Regulatory Muscular Dystrophies General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine Mice 03 medical and health sciences 0302 clinical medicine Immune system medicine Animals Regeneration Muscle Skeletal education Glycoproteins 030304 developmental biology 0303 health sciences education.field_of_study Innate immune system Biochemistry Genetics and Molecular Biology(all) Skeletal muscle FOXP3 hemic and immune systems Cell biology Mice Inbred C57BL medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Intercellular Signaling Peptides and Proteins Transcriptome |
| Zdroj: | Cell. 155:1282-1295 |
| ISSN: | 0092-8674 |
| DOI: | 10.1016/j.cell.2013.10.054 |
| Popis: | SummaryLong recognized to be potent suppressors of immune responses, Foxp3+CD4+ regulatory T (Treg) cells are being rediscovered as regulators of nonimmunological processes. We describe a phenotypically and functionally distinct population of Treg cells that rapidly accumulated in the acutely injured skeletal muscle of mice, just as invading myeloid-lineage cells switched from a proinflammatory to a proregenerative state. A Treg population of similar phenotype accumulated in muscles of genetically dystrophic mice. Punctual depletion of Treg cells during the repair process prolonged the proinflammatory infiltrate and impaired muscle repair, while treatments that increased or decreased Treg activities diminished or enhanced (respectively) muscle damage in a dystrophy model. Muscle Treg cells expressed the growth factor Amphiregulin, which acted directly on muscle satellite cells in vitro and improved muscle repair in vivo. Thus, Treg cells and their products may provide new therapeutic opportunities for wound repair and muscular dystrophies. |
| Databáze: | OpenAIRE |
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