Antibiotic exposure and asthma development in children with allergic rhinitis
Autor: | Yen-Chun Chen, Chih-Hsing Hung, Yi-Ching Lin, Hsin-Yi Huang, Wei-Ju Yeh, Chang-Hung Kuo, Ting-Yi Wu, Yu-Han Chang, Ming-Yii Huang |
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Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Microbiology (medical) medicine.medical_specialty Adolescent medicine.drug_class 030106 microbiology Antibiotics lcsh:QR1-502 Taiwan Allergic rhinitis lcsh:Microbiology 03 medical and health sciences 0302 clinical medicine Internal medicine Odds Ratio Humans Immunology and Allergy Medicine In patient 030212 general & internal medicine Medical prescription Child Children Asthma Dose-Response Relationship Drug General Immunology and Microbiology business.industry Antibiotic exposure Amoxicillin General Medicine Odds ratio medicine.disease Rhinitis Allergic Anti-Bacterial Agents respiratory tract diseases Penicillin Infectious Diseases Child Preschool Female Macrolides business medicine.drug |
Zdroj: | Journal of Microbiology, Immunology and Infection, Vol 53, Iss 5, Pp 803-811 (2020) |
ISSN: | 1684-1182 |
Popis: | Purpose Early-life antibiotic use may be associated with asthma, yet whether this association also exists in patients with allergic rhinitis (AR) remains unknown. We investigated the association between antibiotic exposure and asthma development in AR children. Methods AR patients less than 18 year-old were enrolled from the Taiwan National Health Insurance Database, which reported information from 2005 to 2010. The case group was defined as having newly developed asthma, and the control group was defined as never having an asthma diagnosis. The age of first exposure to antibiotic prescriptions and antibiotic exposure records preceding 5 years before the first asthma diagnosis were obtained from drug prescription records. The odds ratio (OR) was examined after adjusting for age, gender, resident urbanization, underlying medical disorders and medications. Results A total of 3236 AR patients with newly developed asthma and 9708 AR patients without asthma were included in this study. Antibiotic exposure before the age of 3 years was not associated with asthma development. Preceding 5-year antibiotic exposure increased the risk of asthma development with a dose-response relationship, even for antibiotics with low cumulative defined daily doses (adjusted OR 1.40, 95% CI 1.12–1.75). Preceding 5-year exposure to penicillin and macrolide significantly increased the risk of asthma when diagnosed before age 12 in AR patients, but this was not statistically significant when asthma diagnosed after age 12. Conclusion Preceding 5-year antibiotic exposure, particularly to penicillin group of amoxicillin and macrolides, is associated with the risk of asthma development before age 12 in AR children. |
Databáze: | OpenAIRE |
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