Effect of calcitonin treatment on the natural course of bone demineralization in Paget's disease
| Autor: | Sang H. Toh, Paul H. Brown, C. Claunch |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
musculoskeletal diseases
Calcitonin Male medicine.medical_specialty Aging Endocrinology Diabetes and Metabolism Clinical Biochemistry Osteoporosis Biochemistry Bone and Bones Endocrinology Internal medicine medicine Humans Longitudinal Studies Prospective Studies Prospective cohort study Natural course Minerals business.industry Biochemistry (medical) Osteitis Deformans Middle Aged medicine.disease Alkaline Phosphatase Paget s disease Demineralization Photon absorptiometry business |
| Zdroj: | The Journal of clinical endocrinology and metabolism. 56(2) |
| ISSN: | 0021-972X |
| Popis: | Numerous studies have been done to determine the effects of long term calcitonin (CT) treatment on Paget's disease of bone, but very few studies have been undertaken to determine the long term CT effect on nonpagetic bone in man. Because of conflicting results of the CT effect on osteoporosis and also for further understanding of the role of CT on normal bone, we conducted a longitudinal prospective study on the effect of CT treatment on nonpagetic bone in patients with Paget's disease using monoenergetic photon absorptionmetry method. Patients with Paget's disease were given salmon CT daily for a period of 3 yr, the bone mineral content (BMC) in the nonpagetic distal radius was measured periodically for 3 yr, and the data were compared with those of the control group of patients with Paget's disease not receiving CT treatment. It was found that the control group showed a persistent gradual decrease in BMC during the study period of 3 yr, but the CT-treated group showed no decrease in BMC during the 3-yr period of treatment. Our study suggests that CT treatment may delay the natural course of bone demineralization with aging in patients with Paget's disease. |
| Databáze: | OpenAIRE |
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