Evidence of two distinct phylogenetic lineages of dog rabies virus circulating in Cambodia
| Autor: | Paul F. Horwood, Philippe Buchy, Sotheary In, Jean-Marc Reynes, Veasna Duong, Sivuth Ong, Arnaud Tarantola, A. E. Metlin, Hervé Bourhy, Channa Mey |
|---|---|
| Přispěvatelé: | Unité de Virologie, Institut Pasteur du Cambodge-Réseau International des Instituts Pasteur ( RIIP ), Institut Pasteur du Cambodge, Biologie des Infections Virales Émergentes ( UBIVE ), Institut Pasteur [Paris], Dynamique des Lyssavirus et Adaptation à l'Hôte, Unité d'Épidémiologie et de Santé Publique, GlaxoSmithKline, Glaxo Smith Kline, Unité de Virologie / Virology Unit [Phnom Penh], Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Réseau International des Instituts Pasteur (RIIP), Biologie des Infections Virales Émergentes - Biology of Emerging Viral Infections (UBIVE), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP), Dynamique des Lyssavirus et Adaptation à l'Hôte (DyLAH), Institut Pasteur [Paris] (IP), Unité d'Épidémiologie et de Santé Publique [Phnom Penh], Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Most recent common ancestor MESH: Sequence Analysis DNA Lineage (evolution) [SDV]Life Sciences [q-bio] MESH : Nucleocapsid Proteins medicine.disease_cause MESH: Dogs MESH : Dogs MESH : Rabies virus MESH: Animals Dog Diseases Geography Medical Clade Molecular clock MESH: Phylogeny Phylogeny MESH: Evolution Molecular Phylogenetic tree Nucleocapsid Proteins Rabies virus evolution MESH: Rabies virus MESH : Dog Diseases South-East Asia [ SDV.MHEP.MI ] Life Sciences [q-bio]/Human health and pathology/Infectious diseases Infectious Diseases MESH: RNA Viral [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology RNA Viral Cambodia Rabies epidemiology Microbiology (medical) MESH : Geography Medical Rabies MESH: Dog Diseases 030106 microbiology Biology Microbiology [ SDV.MP.VIR ] Life Sciences [q-bio]/Microbiology and Parasitology/Virology Evolution Molecular 03 medical and health sciences Dogs MESH: Rabies Phylogenetics MESH: Geography Medical Genetics medicine Animals MESH : RNA Viral MESH : Evolution Molecular Molecular Biology Ecology Evolution Behavior and Systematics Molecular epidemiology [ SDV ] Life Sciences [q-bio] MESH : Cambodia MESH: Cambodia Rabies virus MESH : Phylogeny MESH: Nucleocapsid Proteins Sequence Analysis DNA Virology 030104 developmental biology Evolutionary biology MESH : Rabies MESH : Animals Canine rabies MESH : Sequence Analysis DNA |
| Zdroj: | Infection, Genetics and Evolution Infection, Genetics and Evolution, Elsevier, 2016, 38, pp.55-61. 〈10.1016/j.meegid.2015.12.011〉 Infection, Genetics and Evolution, 2016, 38, pp.55-61. ⟨10.1016/j.meegid.2015.12.011⟩ Infection, Genetics and Evolution, Elsevier, 2016, 38, pp.55-61. ⟨10.1016/j.meegid.2015.12.011⟩ |
| ISSN: | 1998-2011 1567-1348 1567-7257 |
| DOI: | 10.1016/j.meegid.2015.12.011〉 |
| Popis: | International audience; This first extensive retrospective study of the molecular epidemiology of dog rabies in Cambodia included 149 rabies virus (RABV) entire nucleoprotein sequences obtained from 1998-2011. The sequences were analyzed in conjunction with RABVs from other Asian countries. Phylogenetic reconstruction confirmed the South-East Asian phylogenetic clade comprising viruses from Cambodia, Vietnam, Thailand, Laos and Myanmar. The present study represents the first attempt to classify the phylogenetic lineages inside this clade, resulting in the confirmation that all the Cambodian viruses belonged to the South-East Asian (SEA) clade. Three distinct phylogenetic lineages in the region were established with the majority of viruses from Cambodia closely related to viruses from Thailand, Laos and Vietnam, forming the geographically widespread phylogenetic lineage SEA1. A South-East Asian lineage SEA2 comprised two viruses from Cambodia was identified, which shared a common ancestor with RABVs originating from Laos. Viruses from Myanmar formed separate phylogenetic lineages within the major SEA clade. Bayesian molecular clock analysis suggested that the time to most recent common ancestor (TMRCA) of all Cambodian RABVs dated to around 1950. The TMRCA of the Cambodian SEA1 lineage was around 1964 and that of the SEA2 lineage was around 1953. The results identified three phylogenetically distinct and geographically separated lineages inside the earlier identified major SEA clade, covering at least five countries in the region. A greater understanding of the molecular epidemiology of rabies in South-East Asia is an important step to monitor progress on the efforts to control canine rabies in the region. |
| Databáze: | OpenAIRE |
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