Surgical resection of locally advanced primary transverse colon cancer—not a worse outcome in stage II tumor

Autor: Jeng-Fu You, Yau-Tong You, Chien-Yuh Yeh, Wen-Sy Tasi, Chung-Wei Fan, Jinn-Shiun Chen, Pao-Shiu Hsieh, Reiping Tang, Jeng-Yi Wang, Hsin-Yuan Hung, Jy-Ming Chiang, Chung-Rong Changchien
Rok vydání: 2011
Předmět:
Zdroj: International Journal of Colorectal Disease. 26:859-865
ISSN: 1432-1262
0179-1958
DOI: 10.1007/s00384-011-1146-3
Popis: In locally advanced primary transverse colon cancer, a tumor may cause perforation or invade adjacent organs. Extensive resection is the best choice of treatment, but such procedures must be weighed against the potential survival benefits. This study was performed to identify the clinicopathological features and treatment outcomes of such tumors. We retrospectively reviewed the database of the Colorectal Cancer Registry of Chang Gung Memorial Hospital between February 1995 and December 2005. Patients with colon cancer sited between the hepatic and splenic flexure that involved an adjacent organ without distant metastasis were defined as having locally advanced transverse colon cancer. A total of 827 patients who underwent surgery for transverse primary colon cancer were enrolled in the study. Stage II and stage III colon cancer were diagnosed in 548 patients. Thirty-two (5.8%) patients were diagnosed with locally advanced tumors. Multivariate analysis revealed that stage III, preoperative carcinoembryonic antigen ≥5 ng/mL, a tumor with perforation or obstruction, and the presence of a locally advanced tumor were significant prognostic factors for both overall and cancer-specific survival. Postoperative morbidity rates differed significantly between the locally advanced and non-locally advanced tumor groups (22.7% vs. 12.3%, P
Databáze: OpenAIRE
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