Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction
| Autor: | Patricio Lopez-Jaramillo, Carlos Hernandez-Cassis, Carlos Cure-Cure |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Male
medicine.medical_specialty Goiter medicine.medical_treatment Clinical Biochemistry Urology chemistry.chemical_element Growth Iodine Biochemistry Short stature Thyroid dysfunction Internal medicine medicine Humans Child Chemotherapy business.industry Final height Thyroid General Medicine medicine.disease Thyroid Diseases Body Height Thyroxine Endocrinology medicine.anatomical_structure chemistry El Niño Child Preschool Female medicine.symptom business |
| Zdroj: | European journal of clinical investigation. 25(6) |
| ISSN: | 0014-2972 |
| Popis: | The effect of thyroid replacement therapy (TRT) was evaluated in 372 children with minimal thyroid dysfunction (MTD; augmented TSH response to TRH, deficient iodine consumption, goiter, short stature and retarded bone age), by comparison of pre- with post-observation height in periods of 6 months with and without TRT alternated. A significant (P < 0.05) height recovery was observed when children received TRT; however, during the period without TRT they showed a negative height recovery. Additionally, we followed 51 children with MTD who were observed from Tanner I until final height. The group with L-thyroxine (n = 43) during all follow-up (97 months) showed an important recovery in height (SDS-H = 1.67 +/- 0.93 vs. 1.08 +/- 0.74) which when compared with the untreated group (n = 8; 114 months; SDS-H = -1.50 +/- 0.83 vs. -1.93 +/- 0.33) was significant (P < 0.001). |
| Databáze: | OpenAIRE |
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