A structurally diverse library of safe-by-design citrem-phospholipid lamellar and non-lamellar liquid crystalline nano-assemblies
| Autor: | Peter P. Wibroe, Intan Diana Mat Azmi, Heinz Amenitsch, Lin-Ping Wu, Seyed Moein Moghimi, Ali I. Kazem, Anan Yaghmur |
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| Rok vydání: | 2016 |
| Předmět: |
Nanostructure
Phospholipid Pharmaceutical Science Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Mice chemistry.chemical_compound Phosphatidylcholine Nano Animals Humans Lamellar structure Particle Size Phospholipids Drug Carriers Aqueous solution Liquid crystalline 021001 nanoscience & nanotechnology Liquid Crystals Nanostructures 0104 chemical sciences RAW 264.7 Cells chemistry Drug Design 0210 nano-technology |
| Zdroj: | Journal of Controlled Release. 239:1-9 |
| ISSN: | 0168-3659 |
| Popis: | Non-lamellar liquid crystalline aqueous nanodispersions, known also as ISAsomes (internally self-assembled 'somes' or nanoparticles), are gaining increasing interest in drug solubilisation and bio-imaging, but they often exhibit poor hemocompatibility and induce cytotoxicity. This limits their applications in intravenous drug delivery and targeting. Using a binary mixture of citrem and soy phosphatidylcholine (SPC) at different weight ratios, we describe a library of colloidally stable aqueous and hemocompatible nanodispersions of diverse nanoarchitectures (internal self-assembled nanostructures). This engineered library is structurally stable in human plasma as well as being hemocompatible (non-hemolytic, and poor activator of the complement system). By varying citrem to lipid weight ratio, the nanodispersion susceptibility to macrophage uptake could also be modulated. Finally, the formation of nanodispersions comprising internally V2 (inverse bicontinuous cubic) and H2 (inverse hexagonal) nanoarchitectures was achieved without the use of an organic solvent, a secondary emulsifier, or high-energy input. The tunable binary citrem/SPC nanoplatform holds promise for future development of hemocompatible and immune-safe nanopharmaceuticals. |
| Databáze: | OpenAIRE |
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