A functional cyclooxygenase enzyme is not required for mediation of the pleiotropic effects of human alpha or beta interferon
| Autor: | James T. Forbes, William M. Mitchell, Walter C. Hubbard, Robert J. Workman, Robert L. Forti |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Indomethacin Prostaglandin Alpha interferon Breast Neoplasms Pharmacology Biochemistry Cell Line chemistry.chemical_compound Endocrinology Interferon Viral Interference medicine Humans biology Aspirin Vulvar Neoplasms Cell growth Fibroblasts In vitro Killer Cells Natural IRF1 chemistry Mechanism of action Phenylbutazone Prostaglandin-Endoperoxide Synthases Interferon Type I biology.protein Female Cyclooxygenase medicine.symptom medicine.drug |
| Zdroj: | Prostaglandins. 26(3) |
| ISSN: | 0090-6980 |
| Popis: | Aspirin, indomethacin, and phenbutazone at 50 μM concentration inhibit cyclooxygenase in cultured human foreskin fibroblasts as evidence by the suppression of the major prostaglandin species which aaccumulate in the culture medium. In contrast to data reported for mouse interferon on target mouse cells, these agents have no effect on the introduction of antiviral activity by human α and β interferons. Similarly, these agents have no effect on interferon induced inhibition of cell growth in vitro or on interferon induced natural killer cell activity. |
| Databáze: | OpenAIRE |
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