SARS-CoV-2 and Stroke in a New York Healthcare System

Autor: Kelley Humbert, Jennifer A. Frontera, Erica Scher, Tushar Trivedi, Aaron Lord, Matthew Sanger, Kaitlyn Lillemoe, Koto Ishida, Frank Volpicelli, Eytan Raz, Michael Wachs, Nils Henninger, Omar Tanweer, Shazia Alam, Sun Kim, Jose Torres, Seena Dehkharghani, Shadi Yaghi, Brian Bosworth, Brian Mac Grory
Rok vydání: 2020
Předmět:
Male
diagnosis
coronavirus
Comorbidity
medicine.disease_cause
Severity of Illness Index
Brain Ischemia
Patient Admission
Pandemic
Thrombophilia
Stroke
Coronavirus
biology
Incidence
Original Contribution
Middle Aged
Troponin
Causality
Female
Cardiology and Cardiovascular Medicine
Coronavirus Infections
Adult
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Pneumonia
Viral
Neuroimaging
Blood Sedimentation
Fibrin Fibrinogen Degradation Products
Betacoronavirus
Severity of illness
medicine
Humans
Intensive care medicine
Pandemics
Aged
Retrospective Studies
Advanced and Specialized Nursing
business.industry
SARS-CoV-2
pandemic
COVID-19
medicine.disease
biology.organism_classification
Cerebral Small Vessel Diseases
New York City
Neurology (clinical)
business
Biomarkers
Zdroj: Stroke
ISSN: 1524-4628
Popis: Background and Purpose: With the spread of coronavirus disease 2019 (COVID-19) during the current worldwide pandemic, there is mounting evidence that patients affected by the illness may develop clinically significant coagulopathy with thromboembolic complications including ischemic stroke. However, there is limited data on the clinical characteristics, stroke mechanism, and outcomes of patients who have a stroke and COVID-19. Methods: We conducted a retrospective cohort study of consecutive patients with ischemic stroke who were hospitalized between March 15, 2020, and April 19, 2020, within a major health system in New York, the current global epicenter of the pandemic. We compared the clinical characteristics of stroke patients with a concurrent diagnosis of COVID-19 to stroke patients without COVID-19 (contemporary controls). In addition, we compared patients to a historical cohort of patients with ischemic stroke discharged from our hospital system between March 15, 2019, and April 15, 2019 (historical controls). Results: During the study period in 2020, out of 3556 hospitalized patients with diagnosis of COVID-19 infection, 32 patients (0.9%) had imaging proven ischemic stroke. Cryptogenic stroke was more common in patients with COVID-19 (65.6%) as compared to contemporary controls (30.4%, P =0.003) and historical controls (25.0%, P Conclusions: We observed a low rate of imaging-confirmed ischemic stroke in hospitalized patients with COVID-19. Most strokes were cryptogenic, possibly related to an acquired hypercoagulability, and mortality was increased. Studies are needed to determine the utility of therapeutic anticoagulation for stroke and other thrombotic event prevention in patients with COVID-19.
Databáze: OpenAIRE
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