Functional Properties of Maillard Reaction Products in Food: Antimicrobial Activity of Aminoreductone against Pathogenic Bacteria
| Autor: | Hiroyuki Uked, Vu Hong Son, Hiroaki Takeuchi, Vu Thu Trang, Samira Sarter, Tomoko Shimamura, Lam Xuan Thanh |
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| Rok vydání: | 2013 |
| Předmět: |
Staphylococcus aureus
Imipenem medicine.drug_class Antibiotique General Chemical Engineering Antibiotics Biology medicine.disease_cause Agent pathogène Industrial and Manufacturing Engineering Microbiology Escherichia coli medicine Réaction de maillard Propriété antimicrobienne Q04 - Composition des produits alimentaires Marketing Résistance aux produits chimiques Minimum bactericidal concentration Pseudomonas aeruginosa Pathogenic bacteria Antimicrobial Methicillin-resistant Staphylococcus aureus Produit alimentaire Q03 - Contamination et toxicologie alimentaires Antimicrobien Food Science Biotechnology medicine.drug |
| Zdroj: | Food Science and Technology Research |
| ISSN: | 1881-3984 1344-6606 |
| DOI: | 10.3136/fstr.19.833 |
| Popis: | Antimicrobial activities of aminoreductone (AR), a product formed in the initial stages of the Maillard reaction, were investigated using eight clinical isolates of antibiotic-susceptible/resistant pathogenic bacteria: four Pseudomonas aeruginosa, one multi-drug-resistant Pseudomonas aeruginosa (MDRP), one Escherichia coli, one methicillin-susceptible Staphylococcus aureus, and one methicillin-resistant Staphylococcus aureus (MRSA). AR showed advanced growth inhibition effects compared to antibiotics (amikacin, ciprofloxacin, imipenem and levofloxacin) frequently used for the treatment of infectious diseases, and worked synergistically with these antibiotics. The minimum inhibitory concentrations (MIC) of AR ranged from 13 to 20 mM. The bactericidal activity of AR was dose and time dependent. The minimum bactericidal concentration (MSC) was lower for Gram-negative bacteria (32 to 40 mM). These findings suggest that AR, a naturally formed antimicrobial agent present in thermally processed foods, has promising potential for health promotion and for use in medical practices. (Resume d'auteur) |
| Databáze: | OpenAIRE |
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