Performance in Specific Language Tasks Correlates With Regional Volume Changes in Progressive Aphasia
| Autor: | Bruce L. Miller, Jennifer M. Ogar, John Neuhaus, Simona Maria Brambati, Serena Amici, Maria Luisa Gorno-Tempini, Nina L. Dronkers |
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| Rok vydání: | 2007 |
| Předmět: |
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medicine.medical_specialty Psychometrics Cognitive Neuroscience Statistics as Topic Anomia Aphasiology Brain damage Neuropsychological Tests Audiology Hippocampus Diagnosis Differential Primary progressive aphasia Imaging Three-Dimensional Neuroimaging Aphasia Image Processing Computer-Assisted medicine Humans Dominance Cerebral Aged Brain Mapping Language impairment Neurodegenerative Diseases General Medicine Voxel-based morphometry Middle Aged medicine.disease Magnetic Resonance Imaging Temporal Lobe Frontal Lobe Psychiatry and Mental health Aphasia Primary Progressive Memory Short-Term Neuropsychology and Physiological Psychology Parahippocampal Gyrus Female Atrophy medicine.symptom Differential diagnosis Comprehension Psychology Cognitive psychology |
| Zdroj: | Cognitive and Behavioral Neurology. 20:203-211 |
| ISSN: | 1543-3633 |
| Popis: | Patterns of language impairment have long been used clinically to localize brain damage in stroke patients. The same approach might be useful in the differential diagnosis of progressive aphasia owing to neurodegenerative disease.To investigate whether scores on 4 widely used language tasks correlate with regional gray matter loss in 51 patients with progressive language impairment owing to neurodegenerative disease.Scores in the Boston Naming Test and in the "repetition" "sequential commands" and the "language fluency," subtests of the Western Aphasia Battery were correlated with voxel-wise gray matter volumes using voxel-based morphometry.Significant positive correlations were found between each language task and regional brain volumes: (1) naming and the bilateral temporal lobes; (2) sentence repetition and the left posterior portion of the superior temporal gyrus; (3) sentence comprehension and the left dorsal middle and inferior frontal gyri; and (4) fluency of language production and the left ventral middle and inferior frontal gyri.Performance on specific language tasks corresponds to regional anatomic damage in aphasia owing to neurodegenerative disorders. These language tests might be useful in the differential diagnosis of primary progressive aphasia variants that have been previously associated with damage to corresponding anatomic regions. |
| Databáze: | OpenAIRE |
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