Iron Homeostasis in the CNS: An Overview of the Pathological Consequences of Iron Metabolism Disruption

Autor:	Tracey Rouault, Christina Porras
Rok vydání:	2022
Předmět:	Central Nervous System Iron Organic Chemistry Neurodegenerative Diseases General Medicine Iron Metabolism Disorders Catalysis Computer Science Applications Inorganic Chemistry Animals Homeostasis Humans Physical and Theoretical Chemistry Iron Regulatory Protein 2 Molecular Biology Spectroscopy
Zdroj:	International Journal of Molecular Sciences. 23:4490
ISSN:	1422-0067
Popis:	Iron homeostasis disruption has increasingly been implicated in various neurological disorders. In this review, we present an overview of our current understanding of iron metabolism in the central nervous system. We examine the consequences of both iron accumulation and deficiency in various disease contexts including neurodegenerative, neurodevelopmental, and neuropsychological disorders. The history of animal models of iron metabolism misregulation is also discussed followed by a comparison of three patients with a newly discovered neurodegenerative disorder caused by mutations in iron regulatory protein 2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4c0cc90fd34a9e41df751ac3effa91 https://doi.org/10.3390/ijms23094490 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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