Is Obesity a Potential Risk factor for Poor Prognosis of COVID-19?
| Autor: | Meltem Agca, Zuhal Karakurt, Nazlı Huma Teke, Nermin Ozer Yilmaz, Eylem Tuncay, Elif Yildirim, Dilek Ernam, Simge Yavuz, Tülin Sevim, Reyhan Yildiz, Covid Team, Ipek Ozmen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
business.industry COVID-19 Retrospective cohort study Odds ratio Overweight medicine.disease Intensive care unit Obesity law.invention Obesity SARS-CoV-2 Infectious Diseases Interquartile range law Internal medicine medicine Pharmacology (medical) Original Article medicine.symptom Risk factor business Body mass index |
| Zdroj: | Infection & Chemotherapy |
| ISSN: | 2092-6448 2093-2340 |
| Popis: | BACKGROUND: Coronavirus disease 2019 (COVID-19) continues to cause major mortality and morbidity worldwide even after a year of its emergence. In its early days, hypertension, diabetes, and cardiovascular diseases were noted as poor prognostic factors, while obesity gained attention at a later stage. In the present study, unfavorable clinical outcomes (transfer to the intensive care unit, invasive mechanical ventilation, and mortality) were investigated in obese patients with COVID-19. MATERIALS AND METHODS: In this retrospective study we analyzed patients with positive polymerase chain reaction test in tertiary care hospital between March-May 2020. They were divided into 3 groups according to body mass index (BMI) as normal, overweight, and obese (BMI: 18.5 - 24.99 kg/m², 25 - 29.99 kg/m², and ≥ 30 kg/m², respectively). We compared clinical features and laboratory findings of these groups and recorded adverse clinical outcomes. Multivariate logistic analysis was performed for unfavorable outcomes. RESULTS: There were 99 patients (35%), 116 (41%), and 69 patients (24%) in the normal-weight, overweight, and obese group, respectively. Among all patients, 52 (18%) patients were transferred to the intensive care unit (ICU), 30 (11%) patients received invasive mechanical ventilation (IMV), and 22 patients (8%) died. Obese patients had minimum 1 more comorbidity than normal BMI patients (73% vs. 50%, P = 0.002), and a longer median (interquartile range [IQR]) duration of hospitalization (8 [5 - 12] vs. 6 [5 - 9]) days, P = 0.006). Obese participants had higher concentrations of serum C-reactive protein, procalcitonin, ferritin than non-obese patients (P |
| Databáze: | OpenAIRE |
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