Computer-assisted analysis of human G-banded chromosomes
| Autor: | Ladislav Tomášek, Richard Tuscany, Viktor Kliment, Jan Dvořák |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Chromosome Aberrations
Male Multivariate statistics Generalization business.industry Computers Process (computing) Medicine (miscellaneous) Normal population Pattern recognition Minicomputer law.invention Chromosome Banding Discriminant law Statistics Minicomputers Chromosomes Human Humans Female Artificial intelligence Ploidy Data input business Mathematics |
| Zdroj: | Computers and biomedical research, an international journal. 16(1) |
| ISSN: | 0010-4809 |
| Popis: | The problem of data input into the computer was solved by means of an electromechanical scanner of our own design, which processes information from a positive photocopy. Classification of chromosomes in homologous pairs uses linear functions of discriminant variables. Evaluation of the quality of discriminant variables is based on multivariate generalization of analysis of variance and on Wilks' statistics. The success of the system described depends generally on the reproducibility of banding, on the loss of information during photographic process, on the parameters of the equipment used, as well as on the mathematical methods employed. The results were obtained from an analysis of 27 male and female diploid sets from the normal population and they are fully comparable with other systems, although no direct processing of the sets from the preparation is used. |
| Databáze: | OpenAIRE |
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