Development of Acquired Factor V Inhibitor After Surgical Procedure Without the Use of Fibrin Tissue Adhesives: A Case Report
| Autor: | Hirohisa Hirata, Takeshi Morita, Tetsuya Kasetani, Tomohiro Takeda, Yoshihiko Sakurai |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
factor v bovine thrombin Bethesda unit Gastroenterology Fibrin Internal medicine medicine Coagulation testing tissue adhesive Clotting factor Prothrombin time medicine.diagnostic_test biology business.industry heteroantibody General Engineering Factor V Hematology inhibitor Coagulation General Surgery biology.protein business cross-mixing test autoantibody Partial thromboplastin time |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Development of acquired factor V (FV) inhibitor is a rare coagulation disorder. Production of heteroantibodies against bovine FV, a contaminant in fibrin tissue adhesives, is a common cause of this condition in the field of surgery. The development of recombinant thrombin eliminated contamination of bovine FV, and infrequent use of bovine thrombin has decreased the risk of FV inhibitor development. Here, we report the case of a 43-year-old man who had marked prolongation of prothrombin time and activated partial thromboplastin time after surgery. Mixing coagulation studies with normal plasma and patient’s plasma suggested the presence of an inhibitor. Clotting factor assays revealed that FV activity decreased to |
| Databáze: | OpenAIRE |
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