The Heat Is On: 20-HETE Instructs an Immunosuppressive Phenotype in Cancer-Associated Fibroblasts
| Autor: | Jo Van Ginderachter |
|---|---|
| Přispěvatelé: | Department of Bio-engineering Sciences, Cellular and Molecular Immunology |
| Rok vydání: | 2022 |
| Předmět: |
Fibroblasts/metabolism
Immunosuppression Therapy Cancer Research Carcinoma Non-Small-Cell Lung/metabolism Arachidonic Acid Hot Temperature Lung Neoplasms Fibroblasts Arachidonic Acid/metabolism Catalysis Phenotype Cancer-Associated Fibroblasts Oncology Immunosuppressive Agents/metabolism Carcinoma Non-Small-Cell Lung Tumor Microenvironment 12-Hydroxy-5 8 10 14-eicosatetraenoic Acid/metabolism Humans Lung Neoplasms/metabolism 12-Hydroxy-5 8 10 14-eicosatetraenoic Acid Stromal Cells Immunosuppressive Agents |
| Zdroj: | Cancer Research. 82:3882-3883 |
| ISSN: | 1538-7445 0008-5472 |
| DOI: | 10.1158/0008-5472.can-22-2774 |
| Popis: | Immunotherapy of cancer is a burgeoning field of research since the realization that our immune system intrinsically has the capacity to restrict tumor occurrence and progression. Though strategies to maximize antitumor T-cell activation are well established, the efficacy of these therapies is limited by an insufficient knowledge of the intricate tumor microenvironment and its capacity to thwart antitumor immunity. Chen and colleagues now uncover a novel immunosuppressive pathway in non–small cell lung carcinoma. Overexpression of cytochrome P450F2 in cancer cells increases production of 20-hydroxyeicosatetraenoic acid, which instructs the expression of immunosuppressive molecules in cancer-associated fibroblasts by binding the GPR75 receptor and activating STAT3/c-Jun signaling. This work proposes several innovative therapeutic anchor points that may improve the efficacy of existing immunotherapies. See related article by Chen et al., p. 4016 |
| Databáze: | OpenAIRE |
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