Highly Efficient Antimicrobial Activity of CuxFeyOz Nanoparticles against Important Human Pathogens
| Autor: | Yiping Zhao, Robert J. Maier, Jitendra Pant, Arnab Mondal, Yen-Con Hung, Lu Zhu, David W. Pearson, Yanjun Yang, Jorge E. Vidal, Hitesh Handa, Jane Y. Howe, Stéphane L. Benoit, Jing Xie |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Klebsiella pneumoniae
General Chemical Engineering medicine.disease_cause Article antimicrobial materials lcsh:Chemistry Antibiotic resistance metal oxides medicine General Materials Science Food science copper iron oxides Cytotoxicity Escherichia coli Incubation biology Chemistry Pathogenic bacteria biology.organism_classification Antimicrobial copper oxide lcsh:QD1-999 inorganic nanomaterials drug-resistant bacteria Bacteria cuprous oxide |
| Zdroj: | Nanomaterials Volume 10 Issue 11 Nanomaterials, Vol 10, Iss 2294, p 2294 (2020) |
| ISSN: | 2079-4991 |
| DOI: | 10.3390/nano10112294 |
| Popis: | The development of innovative antimicrobial materials is crucial in thwarting infectious diseases caused by microbes, as drug-resistant pathogens are increasing in both number and capacity to detoxify the antimicrobial drugs used today. An ideal antimicrobial material should inhibit a wide variety of bacteria in a short period of time, be less or not toxic to normal cells, and the fabrication or synthesis process should be cheap and easy. We report a one-step microwave-assisted hydrothermal synthesis of mixed composite CuxFeyOz (Fe2O3/Cu2O/CuO/CuFe2O) nanoparticles (NPs) as an excellent antimicrobial material. The 1 mg/mL CuxFeyOz NPs with the composition 36% CuFeO2, 28% Cu2O and 36% Fe2O3 have a general antimicrobial activity greater than 5 log reduction within 4 h against nine important human pathogenic bacteria (including drug-resistant bacteria as well as Gram-positive and Gram-negative strains). For example, they induced a > 9 log reduction in Escherichia coli B viability after 15 min of incubation, and an ~8 log reduction in multidrug-resistant Klebsiella pneumoniae after 4 h incubation. Cytotoxicity tests against mouse fibroblast cells showed about 74% viability when exposed to 1 mg/mL CuxFeyOz NPs for 24 h, compared to the 20% viability for 1 mg/mL pure Cu2O NPs synthesized by the same method. These results show that the CuxFeyOz composite NPs are a highly efficient, low-toxicity and cheap antimicrobial material that has promising potential for applications in medical and food safety. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|