Topical ofloxacin in the treatment of Pseudomonas keratitis in a rabbit model
| Autor: | Peter J. McDonnell, David C. Gritz, Tae Y. Lee, Arlene Gwon, Bradley B. Hubbard, Diane D.-S. Tang-Liu |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Ofloxacin
medicine.drug_class Administration Topical Antibiotics medicine.disease_cause Eye Infections Bacterial Keratitis Microbiology Aqueous Humor Quinolone antibiotic Tobramycin Medicine Animals Pseudomonas Infections Chromatography High Pressure Liquid Colony-forming unit business.industry Pseudomonas aeruginosa Eye infection medicine.disease Ophthalmology Disease Models Animal Rabbits business medicine.drug |
| Zdroj: | Cornea. 11(2) |
| ISSN: | 0277-3740 |
| Popis: | Ofloxacin, a new quinolone antibiotic with a broad spectrum of activity, is very effective against Pseudomonas aeruginosa in vitro. Its effectiveness was studied in a rabbit model of tobramycin-sensitive P. aeruginosa. Treatment groups received either vehicle, tobramycin 0.3%, or ofloxacin 0.3%. Twelve hours of treatment decreased the bacterial counts from a mean of 2.2 +/- 0.7 x 10(6) colony forming units (cfu) per cornea in the vehicle group to means of 513 +/- 670 and 435 +/- 524 cfu in the tobramycin and ofloxacin groups, respectively. This decrease in bacterial counts was statistically significant (p = 0.001 for tobramycin and ofloxacin each compared with control, p = 0.86 for tobramycin compared with ofloxacin). After seven days, all antibiotic-treated corneas were sterile and the epithelial defects healed at comparable rates. Aqueous humor drug levels were higher in infected eyes without an intact epithelium (p = 0.02); in eyes with intact epithelium, concentrations of ofloxacin were higher than were those of tobramycin (p = 0.002). In this animal model, ofloxacin proved to be an effective antibiotic with no evidence of toxicity. |
| Databáze: | OpenAIRE |
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