Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence
| Autor: | Verena Königer, D. Scott Merrell, Roman Andriiovych Moskalenko, Rainer Haas, Thomas Borén, Sara Henriksson, Jafar Mahdavi, Abhijit Chowdhury, Johan Ögren, Anders Hofer, Jay V. Solnick, Dan Danielsson, Sara K. Lindén, Dag Ilver, Konstantinos S. Papadakos, Susanne Vikström, Jörgen Ådén, Jan Holgersson, Gerhard Gröbner, Alexej Schmidt, Jeanna Bugaytsova, Oscar Björnham, Göran O. Bylund, Rolf Sjöström, Stefan Oscarson, Dionyssios N. Sgouras, Lori M. Hansen, Yevgen A Chernov, Anders Esberg, Kristof Moonens, Christopher Aisenbrey, Charles Kelly, Ludmilla A. Morozova-Roche, Jeannette M. Whitmire, Beatriz Martinez-Gonzalez, Asish K. Mukhopadhyay, Angela Eldridge, Nicklas Strömberg, Robert H. Gilman, Andre Dubois, Lars Engstrand, Staffan Schedin, Brett A. Chromy, Justine Younson, Matthew Goldman, Anna Shevtsova, Macarena P. Quintana-Hayashi, Hui Liu, Magnus Unemo, Lena Rakhimova, Anna Åberg, Sebastian Suerbaum, Anna Arnqvist, Pär Gideonsson, Maréne Landström, Douglas E. Berg, Kristoffer Brännström, Anders Olofsson, Melissa Mendez, G. Balakrish Nair, Han Remaut |
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| Přispěvatelé: | Umeå University, School of Life Sciences, University of Nottingham, UK (UON), Sahlgrenska Academy at University of Gothenburg [Göteborg], Université libre de Bruxelles (ULB), VIB-VUB Center for Structural Biology [Bruxelles], VIB [Belgium], Sumy State University, Max Von Pettenkofer Institute (MVP), Ludwig-Maximilians-Universität München (LMU), Uniformed Services University of the Health Sciences (USUHS), King‘s College London, Johns Hopkins Bloomberg School of Public Health [Baltimore], Johns Hopkins University (JHU), School of Digestive and Liver Diseases [Kolkata] (SDLD), National Institute of Cholera and Enteric Diseases, Translational Health Science and Technology Institute [Faridabad] (THSTI), Institut Pasteur Hellénique, Réseau International des Instituts Pasteur (RIIP), Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Karolinska Institutet [Stockholm], Örebro University Hospital [Örebro, Sweden], Hannover Medical School [Hannover] (MHH), German Center for Infection Research - partner site Hannover-Braunschweig (DZIF), School of Chemistry and Chemical Biology (UCD), University College Dublin [Dublin] (UCD), University of California [Davis] (UC Davis), University of California, German Center for Infection Research, Partnersite Munich (DZIF), Département d'Informatique [Bruxelles] (ULB), Faculté des Sciences [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), University of California [San Diego] (UC San Diego), This work was supported by grants from Vetenskapsrådet (VR/M) to T.B. and S.K.L., Cancerfonden to T.B. and A.A., VR/NT to A.A. and S. Schedin, Formas to S.K.L., the J.C. Kempe and Seth M. Kempe Memorial Foundation, the Knut and Alice Wallenberg Foundation (2012.0090) to T.B. and M.L., European Union Seventh Framework Program GastricGlycoExplorer ITN grant number 316929 to T.B. and Y.A.C., Magn. Bergvall’s Foundation to S. Schedin, DFG (SFB 900/A1) to S. Suerbaum, DFG (HA2697/16-1) to R.H., FP6 ANR-06-PATHO-00701 ERA-NET and Actions Concertées Inter-Pasteuriennes (ACIP) (2006) to D.N.S., NIH R01DK063041 to D.E.B., NIH CA082312 to D.S.M., NIH AI070803 and AI081037 to J.V.S., CSIR project, India (No. 37(1640)/14/EMR –II) to A.K.M., and VIB and FWO (grants: G033717N and 12H8416N) to K.M. and H.R., This paper is dedicated to the memory of our friend, collaborator, and co-author Dr. Andre Dubois, a great scientist who contributed importantly both intellectually and materially to this project. We thank S. Michopoulos and G. Mantzaris for H. pylori clinical isolates and Ö. Furberg (NoPolo.se), N. Ulander (softplanbangkok.com), S. Lindström, and M. Borén for the digital movie, tech, art, and figure work, respectively., Vrije Universiteit Brussel, Basic (bio-) Medical Sciences, Structural Biology Brussels, Department of Bio-engineering Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
MESH: Hydrogen-Ion Concentration Gastric acidity MESH: Helicobacter Infections/pathology MESH: Helicobacter pylori/physiology Disease adaptation Bacterial Adhesion polymorphism acid responsiveness MESH: Bacterial Adhesion Bacterial Hydrogen-Ion Concentration gastric acidity Adhesins 3. Good health Cell and molecular biology medicine.anatomical_structure Infectious Diseases MESH: Gastric Mucosa/microbiology Medical Microbiology 030106 microbiology Immunology Digestive Diseases - (Peptic Ulcer) Biology blood group antigen-binding adhesion Microbiology Helicobacter Infections diversity Vaccine Related 03 medical and health sciences Virology ABO blood group system Biodefense Gastric mucosa medicine MESH: Helicobacter Infections/microbiology multimerization Adhesins Bacterial subpopulations Helicobacter pylori Prevention gastric cancer MESH: Adhesins Bacterial/metabolism biology.organism_classification [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology MESH: Gastric Mucosa/pathology Bacterial adhesin Chronic infection 030104 developmental biology Emerging Infectious Diseases Gastric Mucosa Parasitology Digestive Diseases |
| Zdroj: | Cell Host and Microbe Cell Host and Microbe, Elsevier, 2017, 21 (3), pp.376-389. ⟨10.1016/j.chom.2017.02.013⟩ Cell host & microbe, vol 21, iss 3 Bugaytsova, J A, Björnham, O, Chernov, Y A, Gideonsson, P, Henriksson, S, Mendez, M, Sjöström, R, Mahdavi, J, Shevtsova, A, Ilver, D, Moonens, K, Quintana-Hayashi, M P, Moskalenko, R, Aisenbrey, C, Bylund, G, Schmidt, A, Åberg, A, Brännström, K, Königer, V, Vikström, S, Rakhimova, L, Hofer, A, Ögren, J, Liu, H, Goldman, M D, Whitmire, J M, Ådén, J, Younson, J, Kelly, C G, Gilman, R H, Chowdhury, A, Mukhopadhyay, A K, Nair, G B, Papadakos, K S, Martinez-Gonzalez, B, Sgouras, D N, Engstrand, L, Unemo, M, Danielsson, D, Suerbaum, S, Oscarson, S, Morozova-Roche, L A, Olofsson, A, Gröbner, G, Holgersson, J, Esberg, A, Strömberg, N, Landström, M, Eldridge, A M, Chromy, B A, Hansen, L M, Solnick, J V, Lindén, S K, Haas, R, Dubois, A, Merrell, D S, Schedin, S, Remaut, H, Arnqvist, A, Berg, D E & Borén, T 2017, ' Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence ', Cell Host & Microbe, vol. 21, no. 3, pp. 376-389 . https://doi.org/10.1016/j.chom.2017.02.013 |
| ISSN: | 1931-3128 |
| DOI: | 10.1016/j.chom.2017.02.013⟩ |
| Popis: | The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid responsiveness differs among strains; often correlates with different intragastric regions and evolves during chronic infection and disease progression; and depends on pH sensor sequences in BabA and on pH reversible formation of high-affinity binding BabA multimers. We propose that BabA's extraordinary reversible acid responsiveness enables tight mucosal bacterial adherence while also allowing an effective escape from epithelial cells and mucus that are shed into the acidic bactericidal lumen andthat bio-selection and changes in BabA bindingproperties through mutation and recombination with babA-related genes are selected by differencesamong individuals and by changes in gastric acidity over time. These processes generate diverse H.pylori subpopulations, in which BabA's adaptive evolution contributes to H.pylori persistence and overt gastric disease. |
| Databáze: | OpenAIRE |
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