Resting energy expenditure in Parkinson’s disease patients under dopaminergic treatment
| Autor: | G. Piuri, S. Caronni, S.A. Faierman, O.V. Donnarumma, Carlotta Bolliri, Chiara Pusani, Giovanna Pinelli, Michela Barichella, Erica Cassani, Gianni Pezzoli, E. Vaccarella, Emanuele Cereda, F. Valentina |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Levodopa Parkinson's disease Endocrinology Diabetes and Metabolism Concordance Medicine (miscellaneous) Disease Body weight Body Mass Index 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Internal medicine medicine Humans In patient Resting energy expenditure 030109 nutrition & dietetics Nutrition and Dietetics business.industry General Neuroscience Significant difference Dopaminergic Reproducibility of Results Calorimetry Indirect Parkinson Disease General Medicine medicine.disease Obesity Endocrinology Case-Control Studies Basal metabolic rate Cardiology Basal Metabolism sense organs Energy Metabolism business Body mass index 030217 neurology & neurosurgery Homeostasis medicine.drug |
| Zdroj: | Nutritional Neuroscience. 25:246-255 |
| ISSN: | 1476-8305 1028-415X |
| Popis: | Weight homeostasis is complex in Parkinson's disease (PD) and body weight changes substantially throughout the course of the disease. We designed a case-control study to i) investigate whether PD is associated with changes in resting energy expenditure (REE), ii) to assess the accuracy of REE predictive equations for healthy people in PD and iii) to eventually construct a new formula. Measured REE (mREE) was compared between 122 PD patients and 122 gender and body mass index (BMI)-matched controls. The accuracy of estimated REE by 5 common equations (Harris/Benedict-1919, Harris/Benedict-1984, Mifflin St. Jeor, WHO/FAO and aggregate formula) was investigated in PD using Bland-Altman analysis and reported as the frequency of accurate predictions (±10%). Concordance correlation coefficients (CCC) were also calculated. Then, we regressed a new REE equation - using gender, age, weight, height and Hoehn-Yahr stage - and validated it in an independent sample (N=100). No significant difference in mREE was recorded between the whole PD sample and healthy controls. However, mREE was increased in patients with BMI≥30 kg/m2 and Hoehn-Yahr stage≥3. Available REE equations showed limited accuracy (accurate prediction [±10%] frequency, PD patients are not commonly characterized by an increase in REE. This is limited to patients suffering from obesity and more severe disease. Common REE equations appear to be inaccurate. The new formula provided better REE estimates and its use can be proposed. |
| Databáze: | OpenAIRE |
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