Prevention of Acute Respiratory Illness in Recruits by Adenovirus (RI-APC-ARD) Vaccine
| Autor: | M. S. Warfield, S. A. Anderson, Reuel A. Stallones, M. R. Hilleman, Ross L. Gauld |
|---|---|
| Rok vydání: | 1956 |
| Předmět: |
Vaccines
biology business.industry Adenoviridae Infections Incidence (epidemiology) Prevalence medicine.disease_cause Placebo Virology General Biochemistry Genetics and Molecular Biology Virus Adenoviridae Vaccination Virus Diseases Immunology medicine biology.protein Humans Respiratory system Neutralizing antibody business |
| Zdroj: | Experimental Biology and Medicine. 92:377-383 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-92-22484 |
| Popis: | SummaryThe development, preparation and field evaluation of a highly effective formalin-killed vaccine against acute respiratory illnesses caused by viruses of the RI (Adenovirus) family has been described. The vaccine, prepared from infected tissue cultures of monkey renal epithelium, contained types 4 and 7 virus and was not injurious upon human injection. In human volunteers given a single 1 ml dose of vaccine intramuscularly, it induced high levels of neutralizing antibody. In 311 recruits, vaccinated at Fort Dix, N. J., it produced a marked reduction in the incidence of acute respiratory illness beginning one week after the initial dose of vaccine; only 4.8% of those receiving RI vaccine were hospitalized for respiratory illness compared with 23.8% of the control group of 313 which received placebo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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