Upconversion luminescence nanoparticles-based immunochromatographic assay for quantitative detection of triamcinolone acetonide in cosmetics
| Autor: | Vivian Zhu, Zhang Shiwei, Feng Ronghu, Heng Zhang, Wang Shifeng, Tianqi Yao, Guiping Hu, Liqiong Chen, Yang Guowu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Ethylene Glycol
Triamcinolone acetonide Silicon dioxide Upconversion luminescence media_common.quotation_subject Nanoparticle Cosmetics 02 engineering and technology 010402 general chemistry Triamcinolone Acetonide 01 natural sciences Analytical Chemistry Antibodies Monoclonal Murine-Derived Mice chemistry.chemical_compound medicine Animals Humans Instrumentation Spectroscopy media_common Immunoassay Detection limit Chromatography Chemistry Silicon Dioxide 021001 nanoscience & nanotechnology Triterpenes Atomic and Molecular Physics and Optics 0104 chemical sciences Luminescent Measurements Nanoparticles 0210 nano-technology Coating antigen Ethylene glycol medicine.drug |
| Zdroj: | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 214:302-308 |
| ISSN: | 1386-1425 |
| Popis: | Triamcinolone acetonide (TCA) abuse in cosmetics is a common phenomenon. A rapid lateral flow immunochromatographic assay (ICA) was developed for the quantitative detection of TCA using a probe based on upconversion luminescence nanoparticles. Lanthanide-doped upconversion nanoparticles (UCNPs) were synthesized in a system comprising water and ethylene glycol, and a silicon dioxide layer was covered at the carboxyl site. A binding site protection strategy was used to decrease the background signal of UCNPs-ICA. Using dexamethasone derivative as a coating antigen, the optimal UCNPs–ICA exhibits good dynamic linear detection for TCA in the range 1.0–100 ng mL−1 with a median inhibitory concentration of 9.8 ng mL−1. The detection limits for TCA in a cosmetic sample are 20 μg kg−1. The pretreatment of samples only needs dilution with water, suggesting the assay can quantitate TCA on-site using a portable upconversion luminescence reader with a cumulative analysis time of only 10 min. |
| Databáze: | OpenAIRE |
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