Familial sinistrality and handedness in patients with first episode schizophrenia: The EUFEST study
| Autor: | S. Dollfus, M. Alary, A. Razafimandimby, D. Prelipceanu, J. K. Rybakowski, M. Davidson, S. Galderisi, J. Libiger, L. G. Hranov, M. Hummer, H. Boter, J. Peuskens, R. S. Kahn, W. W. Fleischhacker, null the EUFEST group |
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| Přispěvatelé: | Centre-Imagerie, Neurosciences, et Application aux Pathologies (CI-NAPS - UMR 6232), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Esquirol [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent [SDV]Life Sciences [q-bio] Population Close relatives First episode schizophrenia Logistic regression Functional Laterality 03 medical and health sciences 0302 clinical medicine Arts and Humanities (miscellaneous) medicine Humans In patient education Psychiatry General Psychology ComputingMilieux_MISCELLANEOUS Family Characteristics education.field_of_study General Medicine medicine.disease 030227 psychiatry Schizophrenia Case-Control Studies [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health Laterality Female Psychology 030217 neurology & neurosurgery |
| Zdroj: | Laterality Laterality, 2012, 17 (2), pp.217-224. ⟨10.1080/1357650X.2011.558510⟩ Laterality, Taylor & Francis, 2012, 17 (2), pp.217-224. ⟨10.1080/1357650X.2011.558510⟩ Laterality: Asymmetries of Body, Brain and Cognition Laterality: Asymmetries of Body, Brain and Cognition, Taylor and Francis, 2012, 17 (2), pp.217-224. ⟨10.1080/1357650X.2011.558510⟩ |
| ISSN: | 1357-650X 1464-0678 |
| DOI: | 10.1080/1357650X.2011.558510⟩ |
| Popis: | The population with schizophrenia is characterised by a leftward shift in handedness-sinistrality. However, findings are inconsistent in chronic patients, and familial sinistrality (FS), defined as the presence of left-handed close relatives, might contribute to the discrepancies. Therefore the aim of this study was to investigate the strength of manual lateralisation in patients with first episode schizophrenia, taking into account familial sinistrality. The Edinburgh Inventory (EI) allowed us to categorise 179 patients from the EUFEST study and 189 controls presenting "strong handedness" (SH: EI absolute value between ∣81∣ and ∣100∣) or "weak-handedness" (WH: EI value between -80 and +80). The nominal logistic regression did not show an FS effect, but a nearly significant interaction between illness and FS (p =.07). There were fewer participants without FS presenting SH among patients (99/151: 65.6%) than among controls (134/164: 81.7%, p =.001). In contrast, the number of participants with FS presenting SH was similar between controls (68%) and patients (75%, p =.57). The presence of left-handed relatives (FS + ) tended to reduce manual lateralisation, but only in controls. This supports the notion that reduced manual lateralisation in schizophrenia is related to the illness rather than to familial left-handedness. |
| Databáze: | OpenAIRE |
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