Effects of chronic mild stress (CMS) on thyroid hormone function in two rat strains
| Autor: | Nassia Kioukia, Ion Christofidis, Katerina Antoniou, Zeta Papadopoulou-Daifoti, Stathis Bekris |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Male
Imipramine Thyrotropin/blood Eating/drug effects Endocrinology Diabetes and Metabolism Thyroid Gland Thyrotropin Antidepressive Agents Tricyclic Thyroid Function Tests Rats Sprague-Dawley Thyroxine/blood Eating Endocrinology Behavior Animal/drug effects health care economics and organizations Triiodothyronine medicine.diagnostic_test Behavior Animal Thyroid Peripheral Psychiatry and Mental health medicine.anatomical_structure Stress Physiological/blood/drug therapy/*physiopathology Thyroid function medicine.drug medicine.medical_specialty Triiodothyronine/blood Thyroid function tests Serum Albumin/metabolism Thyroid-stimulating hormone Species Specificity Stress Physiological health services administration Internal medicine medicine Animals Thyroid Gland/drug effects/*metabolism Rats Wistar Biological Psychiatry Serum Albumin Endocrine and Autonomic Systems business.industry Imipramine/pharmacology Albumin Rats Thyroxine Disease Models Animal Antidepressive Agents Tricyclic/pharmacology Chronic Disease business |
| Popis: | This work was carried out to assess the effects of chronic mild stress (CMS) on thyroid function. The CMS model produced an anhedonic effect (reduced preference to sucrose) in Sprague-Dawley and Wistar rats and this effect was reversed by imipramine (IMI) treatment. The effects of CMS on thyroid function were assessed by measuring tT4 (total Thyroxine), tT3 (total Triiodothyronine), TSH (Thyroid Stimulating Hormone) and fT4 (free Thyroxine) serum levels with appropriate immunoassays. CMS increased tT4 and tT3 serum levels in Sprague-Dawley and Wistar rats, but not TSH and fT4 serum levels. Imipramine (IMI) treatment normalized tT4 values. Albumin which binds a fraction of peripheral tT4 and tT3 was also significantly increased in response to CMS, possibly contributing to tT4 and tT3 elevations. The above findings suggest an impact of CMS on thyroid function, especially in tT4 values the changes being reversed with IMI treatment. Psychoneuroendocrinology |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|