Interleukin-8 as a candidate for thymoma identification and recurrence surveillance

Autor: Jian Gao, Jihong Dong, Chun Jin, Haikun Wang, Wen Hao Yang, Ding Jianyong, Pengjie Yang, Li Wang, Gang Chen, Qibin Leng, Jia-Hao Jiang, Shuzhong Cui, Dian Xiong, Junzhen Liu, Gao Shilin, Aiwu Ke
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Adult
Male
Pathology
medicine.medical_specialty
Thymoma
Science
Immunology
General Physics and Astronomy
chemical and pharmacologic phenomena
General Biochemistry
Genetics and Molecular Biology
Article
Tumour biomarkers
03 medical and health sciences
Young Adult
0302 clinical medicine
hemic and lymphatic diseases
medicine
Biomarkers
Tumor
Humans
Clinical significance
In patient
Interleukin 8
Young adult
lcsh:Science
neoplasms
Aged
Multidisciplinary
medicine.diagnostic_test
Receiver operating characteristic
business.industry
Interleukin-8
Magnetic resonance imaging
General Chemistry
Thymus Neoplasms
Middle Aged
medicine.disease
030104 developmental biology
surgical procedures
operative
030220 oncology & carcinogenesis
Biomarker (medicine)
Female
lcsh:Q
Neoplasm Recurrence
Local
business
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
ISSN: 2041-1723
Popis: Thymoma is the most common tumor of the anterior mediastinum. Routine imaging methods such as computed tomography or magnetic resonance imaging often lead to misdiagnosis between thymoma and other thymic abnormalities. Therefore, urgently needed is to develop a new diagnostic strategy. Here we identify interleukin-8 (IL-8) as a biomarker for auxiliary diagnosis of thymoma. We find that IL-8 levels in naïve T cells are markedly elevated in patients with thymoma compared to those with other thymic tumors. IL-8 levels in naive T cells are significantly decreased after surgical resection in thymoma patients, and rise again when thymoma recurs. A receiver operating characteristic curve analysis shows that IL-8 evaluation performs well in thymoma identification, with high specificities and sensitivities. We also observe significant clinical relevance between IL-8 levels in naïve T cells and clinicopathological features. In conclusion, our study suggests that IL-8 is a biomarker for thymoma identification and recurrence surveillance.
Imaging methods, such as CT or MRI, cannot provide accurate diagnosis between malignant thymomas and other thymic abnormalities. Here the authors show that the levels of IL-8 in circulating naive T cells are elevated in patients with thymoma compared with other thymic masses, proposing IL-8 as a candidate biomarker for thymoma diagnosis and recurrence surveillance.
Databáze: OpenAIRE
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