Interleukin-8 as a candidate for thymoma identification and recurrence surveillance
Autor: | Jian Gao, Jihong Dong, Chun Jin, Haikun Wang, Wen Hao Yang, Ding Jianyong, Pengjie Yang, Li Wang, Gang Chen, Qibin Leng, Jia-Hao Jiang, Shuzhong Cui, Dian Xiong, Junzhen Liu, Gao Shilin, Aiwu Ke |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty Thymoma Science Immunology General Physics and Astronomy chemical and pharmacologic phenomena General Biochemistry Genetics and Molecular Biology Article Tumour biomarkers 03 medical and health sciences Young Adult 0302 clinical medicine hemic and lymphatic diseases medicine Biomarkers Tumor Humans Clinical significance In patient Interleukin 8 Young adult lcsh:Science neoplasms Aged Multidisciplinary medicine.diagnostic_test Receiver operating characteristic business.industry Interleukin-8 Magnetic resonance imaging General Chemistry Thymus Neoplasms Middle Aged medicine.disease 030104 developmental biology surgical procedures operative 030220 oncology & carcinogenesis Biomarker (medicine) Female lcsh:Q Neoplasm Recurrence Local business |
Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020) Nature Communications |
ISSN: | 2041-1723 |
Popis: | Thymoma is the most common tumor of the anterior mediastinum. Routine imaging methods such as computed tomography or magnetic resonance imaging often lead to misdiagnosis between thymoma and other thymic abnormalities. Therefore, urgently needed is to develop a new diagnostic strategy. Here we identify interleukin-8 (IL-8) as a biomarker for auxiliary diagnosis of thymoma. We find that IL-8 levels in naïve T cells are markedly elevated in patients with thymoma compared to those with other thymic tumors. IL-8 levels in naive T cells are significantly decreased after surgical resection in thymoma patients, and rise again when thymoma recurs. A receiver operating characteristic curve analysis shows that IL-8 evaluation performs well in thymoma identification, with high specificities and sensitivities. We also observe significant clinical relevance between IL-8 levels in naïve T cells and clinicopathological features. In conclusion, our study suggests that IL-8 is a biomarker for thymoma identification and recurrence surveillance. Imaging methods, such as CT or MRI, cannot provide accurate diagnosis between malignant thymomas and other thymic abnormalities. Here the authors show that the levels of IL-8 in circulating naive T cells are elevated in patients with thymoma compared with other thymic masses, proposing IL-8 as a candidate biomarker for thymoma diagnosis and recurrence surveillance. |
Databáze: | OpenAIRE |
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