Vascular smooth muscle-derived TRPV1-positive progenitors are a source of cold-induced thermogenic adipocytes
| Autor: | Anushka Gupta, Tian Lian Huang, Yu-Hua Tseng, Farnaz Shamsi, Matthew D. Lynes, Mary E. Piper, Aaron M. Streets, Li-Lun Ho |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Vascular smooth muscle
Receptor Platelet-Derived Growth Factor alpha Endocrinology Diabetes and Metabolism Population Adipose tissue TRPV Cation Channels Muscle Smooth Vascular Article chemistry.chemical_compound Mice Growth factor receptor Adipose Tissue Brown Physiology (medical) Adipocyte Brown adipose tissue Internal Medicine medicine Adipocytes Animals Humans Adipocytes Beige education education.field_of_study biology Mesenchymal stem cell Cell Differentiation Mesenchymal Stem Cells Thermogenesis Cell Biology Adipose Tissue Beige Hematopoietic Stem Cells Cell biology Cold Temperature Mice Inbred C57BL medicine.anatomical_structure Adipocytes Brown chemistry biology.protein Platelet-derived growth factor receptor Body Temperature Regulation |
| Zdroj: | Nature metabolism |
| ISSN: | 2522-5812 |
| Popis: | Brown adipose tissue (BAT) and beige fat function in energy expenditure in part due to their role in thermoregulation, making these tissues attractive targets for treating obesity and metabolic disorders. While prolonged cold exposure promotes de novo recruitment of brown adipocytes, the exact sources of cold-induced thermogenic adipocytes are not completely understood. Here, we identify transient receptor potential cation channel subfamily V member 1 (Trpv1)+ vascular smooth muscle (VSM) cells as previously unidentified thermogenic adipocyte progenitors. Single-cell RNA sequencing analysis of interscapular brown adipose depots reveals, in addition to the previously known platelet-derived growth factor receptor (Pdgfr)α-expressing mesenchymal progenitors, a population of VSM-derived adipocyte progenitor cells (VSM-APC) expressing the temperature-sensitive cation channel Trpv1. We demonstrate that cold exposure induces the proliferation of Trpv1+ VSM-APCs and enahnces their differentiation to highly thermogenic adipocytes. Together, these findings illustrate the landscape of the thermogenic adipose niche at single-cell resolution and identify a new cellular origin for the development of brown and beige adipocytes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink