Physical exercise and fatigue in advanced gastrointestinal cancer during chemotherapy
| Autor: | Alfredo Navigante, Pablo Cresta Morgado, María Laura Daud, Helca Dos Santos Regis, Martín Kolberg, Carla Marazzi, Velia Lobbe, Andrea Alejandra González, Gustavo De Simone |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | BMJ Supportive & Palliative Care. 13:218-227 |
| ISSN: | 2045-4368 2045-435X |
| Popis: | ObjectivesThis study was aimed to analyse the effect of a patient-oriented modality of physical exercise (programmed and directed physical exercise (PDPE)) on cancer-related fatigue (CRF) and quality of life (QoL). The secondary aim was to evaluate changes in body composition and skeletal muscle function during the study in patients with and without PDPE.MethodsA prospective randomised study was conducted to analyse the impact of PDPE on CRF and QoL. Patients were selected before the development of CRF to set the intervention before its appearance. A high probability CRF population was chosen: patients with advanced gastrointestinal cancer undergoing chemotherapy with weight loss (≥5%) over the last 6 months. PDPE consisted of a programme of exercise delivered weekly and adjusted to patients’ medical conditions. Four visits were planned (weeks 0, 4, 8 and 12). QoL, CRF, body composition and skeletal muscle function were evaluated in each visit.ResultsFrom 101 patients recruited, 64 were considered evaluable, with three or four visits completed (n=30 control, n=34 PDPE group). Satisfactory compliance of ≥50% to the PDPE programme was seen in 47%. A reduction in the severity of fatigue was detected in the PDPE group (p=0.019), being higher in the subgroup of satisfactory compliance (pConclusionPDPE reduced the severity of fatigue and improved QoL. The difference in endurance would explain the results seen in the severity of fatigue. |
| Databáze: | OpenAIRE |
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