Cognitive deterioration in adult epilepsy: Does accelerated cognitive ageing exist?
| Autor: | Antoine Bernas, Lem Breuer, B Albert Aldenkamp, Paul Boon, AG Anton Tijhuis, Svitlana Zinger, Debby Klooster, de Aja Anton Louw, Rmh René Besseling, Jwm Jan Bergmans, Werner H. Mess |
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| Přispěvatelé: | MUMC+: HZC Klinische Neurofysiologie (5), Klinische Neurowetenschappen, RS: CARIM - R3.03 - Cerebral small vessel disease, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, Signal Processing Systems, Electrical Engineering, Electromagnetics, Video Coding & Architectures, Biomedical Diagnostics Lab |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Traumatic brain injury Cognitive Neuroscience Cognitive decline Context (language use) Status epilepticus Cognitive trajectory 03 medical and health sciences Behavioral Neuroscience Epilepsy Cognition 0302 clinical medicine medicine Humans Psychiatry Cognitive reserve Cognitive ageing Cognitive deterioration Brain medicine.disease 030104 developmental biology Neuropsychology and Physiological Psychology Risk factors Cognitive Aging Ageing Accelerated cognitive ageing medicine.symptom Psychology 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience and Biobehavioral Reviews, 64, 1-11. Elsevier Science Neuroscience and Biobehavioral Reviews, 64, 1-11. Elsevier |
| ISSN: | 0149-7634 |
| DOI: | 10.1016/j.neubiorev.2016.02.004 |
| Popis: | A long-standing concern has been whether epilepsy contributes to cognitive decline or so-called 'epileptic dementia'. Although global cognitive decline is generally reported in the context of chronic refractory epilepsy, it is largely unknown what percentage of patients is at risk for decline. This review is focused on the identification of risk factors and characterization of aberrant cognitive trajectories in epilepsy. Evidence is found that the cognitive trajectory of patients with epilepsy over time differs from processes of cognitive ageing in healthy people, especially in adulthood-onset epilepsy. Cognitive deterioration in these patients seems to develop in a 'second hit model' and occurs when epilepsy hits on a brain that is already vulnerable or vice versa when comorbid problems develop in a person with epilepsy. Processes of ageing may be accelerated due to loss of brain plasticity and cognitive reserve capacity for which we coin the term 'accelerated cognitive ageing'. We believe that the concept of accelerated cognitive ageing can be helpful in providing a framework understanding global cognitive deterioration in epilepsy. |
| Databáze: | OpenAIRE |
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