Insulin resistance, glucose intolerance, and hyperinsulinemia in patients with microvascular angina
| Autor: | Wayne Huey-Herng Sheu, Martin M.-T. Fuh, Mason Mao-Shin Young, Gerald M. Reaven, Chii Yuan Jeng, Y.-D. Ida Chen |
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| Rok vydání: | 1993 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Impaired glucose tolerance Endocrinology Insulin resistance Reference Values Internal medicine Hyperinsulinism medicine Hyperinsulinemia Humans Insulin Pancreatic hormone Microvascular Angina Glucose tolerance test medicine.diagnostic_test business.industry Glucose Tolerance Test Middle Aged medicine.disease Pathophysiology Somatostatin Glucose Female Insulin Resistance business |
| Zdroj: | Metabolism: clinical and experimental. 42(9) |
| ISSN: | 0026-0495 |
| Popis: | Plasma glucose and insulin responses to oral glucose and insulin-mediated glucose disposal were determined in 20 patients with microvascular angina and 20 normal volunteers who were similar in terms of age, gender distribution, and degree of obesity. Plasma glucose and insulin responses to a 75-g oral glucose challenge were significantly higher in those with microvascular angina (P.001), as were steady-state plasma glucose concentrations after a 180-minute infusion of somatostatin, glucose, and insulin (12.2 +/- 1.0 v 7.6 +/- 0.6 mmol/L, P.001). Since steady-state plasma insulin concentrations were similar in the two groups (627 +/- 32 v 631 +/- 29 pmol/L), these data indicate that patients with microvascular angina are insulin-resistant, glucose-intolerant, and hyperinsulinemic compared with a matched group of normal volunteers. |
| Databáze: | OpenAIRE |
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