The HIV-1 antibody response: a footprint of the viral reservoir in children vertically infected with HIV
| Autor: | Nicola Cotugno, Margaret M. McManus, Katherine Luzuriaga, Salvatore Rocca, Paolo Palma, Paolo Rossi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Epidemiology Anti-HIV Agents Immunology Human immunodeficiency virus (HIV) HIV Infections HIV Antibodies medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine Virology Medicine Humans 030212 general & internal medicine biology business.industry Infectious disease transmission Infant Viral Load Settore MED/38 030112 virology Antiretroviral therapy Infectious Disease Transmission Vertical Infectious Diseases Antibody response DNA Viral biology.protein HIV-1 Therapeutic vaccine Antibody business Viral persistence Viral load |
| Zdroj: | Lancet HIV |
| ISSN: | 2352-3018 |
| Popis: | Several assays have recently been developed to measure and characterize the replication-competent HIV-1 reservoir, which constitutes the barrier to cure. To date, application of these assays to studies in children and in limited-resource settings has been limited, primarily due to their expense, large required blood volumes, high costs, and labor-intensive technologies. In vertically HIV-1 infected children who initiated suppressive antiretroviral therapy (ART) regimens in infancy, HIV-1 specific antibody levels are associated with levels of viral persistence and could be used as tools to estimate the size of the residual latent reservoir on ART. This may be particularly useful for screening these children on suppressive ART for enrollment into therapeutic vaccine and other protocols aimed at achieving HIV-1 remission. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|