Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions
| Autor: | Ju-Hee Kang, Je Kyung Seong, Seung Hyun Oh, Hyun Jin Jung, Keunwook Lee, Seongwon Pak |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Chemokine Cell Adhesion Molecules Neuronal IBD Adhesion (medicine) Inflammation Catalysis Article lcsh:Chemistry Inorganic Chemistry Mice Ninjurin1 Cell Movement medicine Cell Adhesion Animals Secretion Nerve Growth Factors Physical and Theoretical Chemistry lcsh:QH301-705.5 Molecular Biology Pathological Spectroscopy Cells Cultured Mice Knockout biology Chemistry Organic Chemistry Cell migration General Medicine Nerve injury medicine.disease Colitis Computer Science Applications Mice Inbred C57BL Intestinal Diseases lcsh:Biology (General) lcsh:QD1-999 myeloid cells Myeloid cells Cancer research biology.protein Female IL1β medicine.symptom Signal Transduction |
| Zdroj: | International Journal of Molecular Sciences Volume 21 Issue 2 International Journal of Molecular Sciences, Vol 21, Iss 2, p 614 (2020) |
| ISSN: | 1422-0067 |
| Popis: | Nerve injury-induced protein 1 (Ninjurin1, Ninj1) is a cell-surface adhesion molecule that regulates cell migration and attachment. This study demonstrates the increase in Ninj1 protein expression during development of intestinal inflammation. Ninj1-deficient mice exhibited significantly attenuated bodyweight loss, shortening of colon length, intestinal inflammation, and lesser pathological lesions than wild-type mice. Although more severe inflammation and serious lesions are observed in wild-type mice than Ninj1-deficient mice, there were no changes in the numbers of infiltrating macrophages in the inflamed tissues obtained from WT and Ninj1-deficient mice. Ninj1 expression results in activation of macrophages, and these activated macrophages secrete more cytokines and chemokines than Ninj1-deficient macrophages. Moreover, mice with conditional deletion of Ninj1 in myeloid cells (Ninj1fl/fl Lyz-Cre+) alleviated experimental colitis compared with wild-type mice. In summary, we propose that the Ninj1 in myeloid cells play a pivotal function in intestinal inflammatory conditions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|