Reduced hepcidin expression enhances iron overload in patients with HbE/β‑thalassemia: Α comparative cross‑sectional study
| Autor: | Imilia Ismail, Hanan Kamel M. Saad, Abdullah Saleh Al‑Wajeeh, Muhammad Farid Johan, Wan Rohani Wan Taib, Hamid Ali Nagi Al‑Jamal |
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| Rok vydání: | 2021 |
| Předmět: |
ferroportin1
congenital hereditary and neonatal diseases and abnormalities Cancer Research medicine.medical_specialty Thalassemia β-thalassemia trait Immunology and Microbiology (miscellaneous) Hepcidin hemic and lymphatic diseases Internal medicine Medicine iron-homeostasis hemoglobin E trait Oncogene biology medicine.diagnostic_test business.industry ferritin virus diseases Articles General Medicine medicine.disease Molecular medicine Ferritin Endocrinology Real-time polymerase chain reaction hemoglobin E/β-thalassemia Hemoglobin E biology.protein Serum iron hepcidin business |
| Zdroj: | Experimental and Therapeutic Medicine |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2021.10838 |
| Popis: | Iron homeostasis is regulated by hepcidin (HEPC) that controls the dietary iron absorption and iron recycling. HEPC deficiency contributes to iron overload in β-thalassemia patients. The present study aimed to investigate the correlation between HEPC concentration and serum iron status among hemoglobin E (HbE)/β-thalassemia patients and their parents (HbE trait and β-thalassemia trait) compared with healthy controls. This study is a comparative cross-sectional study in which iron profile and HEPC level were examined in 65 HbE/β-thalassemia patients (pretransfusion) and 65 parents at the Hospital Sultanah Nur Zahirah and in 130 students as healthy controls from Univesiti Sultan Zainal Abidin, Terengganu, Malaysia. Furthermore, six samples from each group (HbE/β-thalassemia patients, parents and healthy controls) were randomly selected for gene expression analysis of HEPC and ferroportin1 (FPN1) using reverse transcription quantitative PCR. The results demonstrated that serum HEPC level were significantly decreased in HbE/β-thalassemia patients and their parents (P |
| Databáze: | OpenAIRE |
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