Curing of UV prints - Assessment of possible toxicological hazard for consumers
Autor: | Ulrike Schuhmacher-Wolz, Eva Kaiser, Melanie Macherey, Thomas Gude, Kathrin Mohr, Evert H. Delbanco, Harry Belz |
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Rok vydání: | 2021 |
Předmět: |
Adult
Ultraviolet Rays Population 010501 environmental sciences Toxicology 030226 pharmacology & pharmacy 01 natural sciences Models Biological Permeability 03 medical and health sciences 0302 clinical medicine Skin surface Humans Computer Simulation education Saliva Sweat Curing (chemistry) 0105 earth and related environmental sciences Skin Coated paper education.field_of_study Chromatography Chemistry Trimethylolpropane triacrylate General Medicine Acrylates Printing Ink |
Zdroj: | Regulatory toxicology and pharmacology : RTP. 124 |
ISSN: | 1096-0295 |
Popis: | In an experimental setting a laboratory analysis of substances migrating from UV prints under mechanical stress into sweat and saliva simulant was performed. The influence of paper type and curing degree on UV prints was investigated. Five substances were identified at concentrations above the limit of detection in the simulants PPG-3 glyceryl triacrylate, ethoxylated trimethylolpropane triacrylate, trimethylolpropane triacrylate, 2/4-isopropylthioxanthone (ITX), and 2,4-diethylthioxanthone (DETX). Migration of the acrylates and photoinitiators into saliva and sweat simulants were increased when the UV inks were printed on uncoated paper in comparison to coated paper. With an exposure scenario considering a person to leaf through 80 pages of UV-printed paper per day while touching each page with a licked fingertip, Risk Characterisation Ratios (RCR) for oral exposure well below 1 were obtained for all five substances indicating no risk for the general population. The three acrylates are classified for skin sensitisation. The migrated amounts per skin surface area of these three were compared with the EC3 value for a hypothetical substance that could be categorised as strong sensitiser (EC3 = 0.1%). The results show that the risk of skin sensitisation even under worst case conditions can be considered as negligible. |
Databáze: | OpenAIRE |
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