Synthesis and stereochemistry of 8,13-diaza-2,3-dimethoxygona-1,3,5(10),9(11)-tetraen-12-one and d-homo derivatives
| Autor: | Lajos Gera, Gábor Tóth, György Göndös, John N. Bridson, Alajos Kálmán |
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| Rok vydání: | 1998 |
| Předmět: |
Models
Molecular Pharmacology Magnetic Resonance Spectroscopy Bicyclic molecule Stereochemistry Chemistry Organic Chemistry Clinical Biochemistry Molecular Conformation Crystal structure Condensation reaction Ring (chemistry) Biochemistry Chemical synthesis chemistry.chemical_compound Endocrinology X-Ray Diffraction Azasteroids Lactam Molecule Stereoselectivity Molecular Biology |
| Zdroj: | Steroids. 63:375-382 |
| ISSN: | 0039-128X |
| DOI: | 10.1016/s0039-128x(98)00011-7 |
| Popis: | From the condensation reaction of O -methylbutyrolactim ( 2 ), O -methylvalerolactim ( 3 ), O -methylcaprolactim ( 4 ) and O -methyl-4- t -butylcaprolactim ( 5 ) with ethyl 6,7-dimethoxy-α-[1-(1,2,3,4-tetrahydro-isoquinolyl)]acetate ( 1 ), 8,13-diaza-2,3-dimethoxygona-1,3,5(10),9(11)-tetraen-12-one ( 6 ) d -homo-derivatives ( 7–9 ), and medium-sized ring cyclic diamides ( 10,11 ) were obtained. The stereoselective reduction of compounds 6–9 by Adam’s platinum catalyst afforded 8,13-diaza-2,3-dimethoxygona-1,3,5(10)-trien-12-one ( 12 ) and its d -homo derivatives ( 13–15 ). The structures of the compounds obtained were established by NMR and X-ray crystallographic analyses. |
| Databáze: | OpenAIRE |
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